diff --git a/Marlin/src/Marlin.cpp b/Marlin/src/Marlin.cpp
index a3646eb12..a78cdf2a6 100644
--- a/Marlin/src/Marlin.cpp
+++ b/Marlin/src/Marlin.cpp
@@ -259,6 +259,9 @@ void setup_powerhold() {
 /**
  * Sensitive pin test for M42, M226
  */
+
+#include "pins/sensitive_pins.h"
+
 bool pin_is_protected(const pin_t pin) {
   static const pin_t sensitive_pins[] PROGMEM = SENSITIVE_PINS;
   for (uint8_t i = 0; i < COUNT(sensitive_pins); i++) {
diff --git a/Marlin/src/gcode/control/M350_M351.cpp b/Marlin/src/gcode/control/M350_M351.cpp
index cd75e7b2b..a83823f31 100644
--- a/Marlin/src/gcode/control/M350_M351.cpp
+++ b/Marlin/src/gcode/control/M350_M351.cpp
@@ -41,17 +41,21 @@ void GcodeSuite::M350() {
 
 /**
  * M351: Toggle MS1 MS2 pins directly with axis codes X Y Z E B
- *       S# determines MS1 or MS2, X# sets the pin high/low.
+ *       S# determines MS1, MS2 or MS3, X# sets the pin high/low.
  */
 void GcodeSuite::M351() {
   if (parser.seenval('S')) switch (parser.value_byte()) {
     case 1:
-      LOOP_XYZE(i) if (parser.seenval(axis_codes[i])) stepper.microstep_ms(i, parser.value_byte(), -1);
-      if (parser.seenval('B')) stepper.microstep_ms(4, parser.value_byte(), -1);
+      LOOP_XYZE(i) if (parser.seenval(axis_codes[i])) stepper.microstep_ms(i, parser.value_byte(), -1, -1);
+      if (parser.seenval('B')) stepper.microstep_ms(4, parser.value_byte(), -1, -1);
       break;
     case 2:
-      LOOP_XYZE(i) if (parser.seenval(axis_codes[i])) stepper.microstep_ms(i, -1, parser.value_byte());
-      if (parser.seenval('B')) stepper.microstep_ms(4, -1, parser.value_byte());
+      LOOP_XYZE(i) if (parser.seenval(axis_codes[i])) stepper.microstep_ms(i, -1, parser.value_byte(), -1);
+      if (parser.seenval('B')) stepper.microstep_ms(4, -1, parser.value_byte(), -1);
+      break;
+    case 3:
+      LOOP_XYZE(i) if (parser.seenval(axis_codes[i])) stepper.microstep_ms(i, -1, -1, parser.value_byte());
+      if (parser.seenval('B')) stepper.microstep_ms(4, -1, -1, parser.value_byte());
       break;
   }
   stepper.microstep_readings();
diff --git a/Marlin/src/inc/Conditionals_post.h b/Marlin/src/inc/Conditionals_post.h
index 326a701af..969a7021c 100644
--- a/Marlin/src/inc/Conditionals_post.h
+++ b/Marlin/src/inc/Conditionals_post.h
@@ -236,26 +236,37 @@
   #define MAX_AUTORETRACT 99
 #endif
 
-// MS1 MS2 Stepper Driver Microstepping mode table
-#define MICROSTEP1 LOW,LOW
-#if ENABLED(HEROIC_STEPPER_DRIVERS)
-  #define MICROSTEP128 LOW,HIGH
-#else
-  #define MICROSTEP2 HIGH,LOW
-  #define MICROSTEP4 LOW,HIGH
-#endif
-#define MICROSTEP8 HIGH,HIGH
-#ifdef __SAM3X8E__
-  #if MB(ALLIGATOR)
-    #define MICROSTEP16 LOW,LOW
-    #define MICROSTEP32 HIGH,HIGH
+// MS1 MS2 MS3 Stepper Driver Microstepping mode table
+#if DISABLED(MICROSTEP_CUSTOM)
+  #define MICROSTEP1 LOW,LOW,LOW
+  #if ENABLED(HEROIC_STEPPER_DRIVERS)
+    #define MICROSTEP128 LOW,HIGH,LOW
   #else
-    #define MICROSTEP16 HIGH,HIGH
+    #define MICROSTEP2 HIGH,LOW,LOW
+    #define MICROSTEP4 LOW,HIGH,LOW
+  #endif
+  #define MICROSTEP8 HIGH,HIGH,LOW
+  #ifdef __SAM3X8E__
+    #if MB(ALLIGATOR)
+      #define MICROSTEP16 LOW,LOW,LOW
+      #define MICROSTEP32 HIGH,HIGH,LOW
+    #else
+      #define MICROSTEP16 HIGH,HIGH,LOW
+    #endif
+  #else
+    #define MICROSTEP16 HIGH,HIGH,LOW
   #endif
-#else
-  #define MICROSTEP16 HIGH,HIGH
 #endif
 
+#define HAS_MICROSTEP1 defined(MICROSTEP1)
+#define HAS_MICROSTEP2 defined(MICROSTEP2)
+#define HAS_MICROSTEP4 defined(MICROSTEP4)
+#define HAS_MICROSTEP8 defined(MICROSTEP8)
+#define HAS_MICROSTEP16 defined(MICROSTEP16)
+#define HAS_MICROSTEP32 defined(MICROSTEP32)
+#define HAS_MICROSTEP64 defined(MICROSTEP64)
+#define HAS_MICROSTEP128 defined(MICROSTEP128)
+
 /**
  * Override here because this is set in Configuration_adv.h
  */
@@ -828,6 +839,7 @@
 #define HAS_Z3_ENABLE     (PIN_EXISTS(Z3_ENABLE))
 #define HAS_Z3_DIR        (PIN_EXISTS(Z3_DIR))
 #define HAS_Z3_STEP       (PIN_EXISTS(Z3_STEP))
+#define HAS_Z3_MICROSTEPS (PIN_EXISTS(Z3_MS1))
 
 // Extruder steppers and solenoids
 #define HAS_E0_ENABLE     (PIN_EXISTS(E0_ENABLE))
@@ -1003,7 +1015,7 @@
 #define HAS_CASE_LIGHT (PIN_EXISTS(CASE_LIGHT) && ENABLED(CASE_LIGHT_ENABLE))
 
 // Digital control
-#define HAS_MICROSTEPS (HAS_X_MICROSTEPS || HAS_Y_MICROSTEPS || HAS_Z_MICROSTEPS || HAS_E0_MICROSTEPS || HAS_E1_MICROSTEPS || HAS_E2_MICROSTEPS || HAS_E3_MICROSTEPS || HAS_E4_MICROSTEPS || HAS_E5_MICROSTEPS)
+#define HAS_MICROSTEPS (HAS_X_MICROSTEPS || HAS_X2_MICROSTEPS || HAS_Y_MICROSTEPS || HAS_Y2_MICROSTEPS || HAS_Z_MICROSTEPS || HAS_Z2_MICROSTEPS || HAS_Z3_MICROSTEPS || HAS_E0_MICROSTEPS || HAS_E1_MICROSTEPS || HAS_E2_MICROSTEPS || HAS_E3_MICROSTEPS || HAS_E4_MICROSTEPS || HAS_E5_MICROSTEPS)
 #define HAS_STEPPER_RESET (PIN_EXISTS(STEPPER_RESET))
 #define HAS_DIGIPOTSS (PIN_EXISTS(DIGIPOTSS))
 #define HAS_MOTOR_CURRENT_PWM (PIN_EXISTS(MOTOR_CURRENT_PWM_XY) || PIN_EXISTS(MOTOR_CURRENT_PWM_Z) || PIN_EXISTS(MOTOR_CURRENT_PWM_E))
diff --git a/Marlin/src/inc/MarlinConfig.h b/Marlin/src/inc/MarlinConfig.h
index e5489886d..226af65a2 100644
--- a/Marlin/src/inc/MarlinConfig.h
+++ b/Marlin/src/inc/MarlinConfig.h
@@ -31,6 +31,8 @@
 
 #include "../pins/pins.h"
 
+#include HAL_PATH(../HAL, spi_pins.h)
+
 #if defined(__AVR__) && !defined(USBCON)
   #define HardwareSerial_h // trick to disable the standard HWserial
 #endif
diff --git a/Marlin/src/module/stepper.cpp b/Marlin/src/module/stepper.cpp
index ed7ef0793..d3ce5b70a 100644
--- a/Marlin/src/module/stepper.cpp
+++ b/Marlin/src/module/stepper.cpp
@@ -2504,53 +2504,136 @@ void Stepper::report_positions() {
    */
 
   void Stepper::microstep_init() {
-    SET_OUTPUT(X_MS1_PIN);
-    SET_OUTPUT(X_MS2_PIN);
+    #if HAS_X_MICROSTEPS
+      SET_OUTPUT(X_MS1_PIN);
+      SET_OUTPUT(X_MS2_PIN);
+      #if PIN_EXISTS(X_MS3)
+        SET_OUTPUT(X_MS3_PIN);
+      #endif
+    #endif
+    #if HAS_X2_MICROSTEPS
+      SET_OUTPUT(X2_MS1_PIN);
+      SET_OUTPUT(X2_MS2_PIN);
+      #if PIN_EXISTS(X2_MS3)
+        SET_OUTPUT(X2_MS3_PIN);
+      #endif
+    #endif
     #if HAS_Y_MICROSTEPS
       SET_OUTPUT(Y_MS1_PIN);
       SET_OUTPUT(Y_MS2_PIN);
+      #if PIN_EXISTS(Y_MS3)
+        SET_OUTPUT(Y_MS3_PIN);
+      #endif
+    #endif
+    #if HAS_Y2_MICROSTEPS
+      SET_OUTPUT(Y2_MS1_PIN);
+      SET_OUTPUT(Y2_MS2_PIN);
+      #if PIN_EXISTS(Y2_MS3)
+        SET_OUTPUT(Y2_MS3_PIN);
+      #endif
     #endif
     #if HAS_Z_MICROSTEPS
       SET_OUTPUT(Z_MS1_PIN);
       SET_OUTPUT(Z_MS2_PIN);
+      #if PIN_EXISTS(Z_MS3)
+        SET_OUTPUT(Z_MS3_PIN);
+      #endif
     #endif
+    #if HAS_Z2_MICROSTEPS
+      SET_OUTPUT(Z2_MS1_PIN);
+      SET_OUTPUT(Z2_MS2_PIN);
+      #if PIN_EXISTS(Z2_MS3)
+        SET_OUTPUT(Z2_MS3_PIN);
+      #endif
+    #endif
+    #if HAS_Z3_MICROSTEPS
+      SET_OUTPUT(Z3_MS1_PIN);
+      SET_OUTPUT(Z3_MS2_PIN);
+      #if PIN_EXISTS(Z3_MS3)
+        SET_OUTPUT(Z3_MS3_PIN);
+      #endif
+    #endif    
     #if HAS_E0_MICROSTEPS
       SET_OUTPUT(E0_MS1_PIN);
       SET_OUTPUT(E0_MS2_PIN);
+      #if PIN_EXISTS(E0_MS3)
+        SET_OUTPUT(E0_MS3_PIN);
+      #endif
     #endif
     #if HAS_E1_MICROSTEPS
       SET_OUTPUT(E1_MS1_PIN);
       SET_OUTPUT(E1_MS2_PIN);
+      #if PIN_EXISTS(E1_MS3)
+        SET_OUTPUT(E1_MS3_PIN);
+      #endif
     #endif
     #if HAS_E2_MICROSTEPS
       SET_OUTPUT(E2_MS1_PIN);
       SET_OUTPUT(E2_MS2_PIN);
+      #if PIN_EXISTS(E2_MS3)
+        SET_OUTPUT(E2_MS3_PIN);
+      #endif
     #endif
     #if HAS_E3_MICROSTEPS
       SET_OUTPUT(E3_MS1_PIN);
       SET_OUTPUT(E3_MS2_PIN);
+      #if PIN_EXISTS(E3_MS3)
+        SET_OUTPUT(E3_MS3_PIN);
+      #endif
     #endif
     #if HAS_E4_MICROSTEPS
       SET_OUTPUT(E4_MS1_PIN);
       SET_OUTPUT(E4_MS2_PIN);
+      #if PIN_EXISTS(E4_MS3)
+        SET_OUTPUT(E4_MS3_PIN);
+      #endif
     #endif
     #if HAS_E5_MICROSTEPS
       SET_OUTPUT(E5_MS1_PIN);
       SET_OUTPUT(E5_MS2_PIN);
+      #if PIN_EXISTS(E5_MS3)
+        SET_OUTPUT(E5_MS3_PIN);
+      #endif
     #endif
     static const uint8_t microstep_modes[] = MICROSTEP_MODES;
     for (uint16_t i = 0; i < COUNT(microstep_modes); i++)
       microstep_mode(i, microstep_modes[i]);
   }
 
-  void Stepper::microstep_ms(const uint8_t driver, const int8_t ms1, const int8_t ms2) {
+  void Stepper::microstep_ms(const uint8_t driver, const int8_t ms1, const int8_t ms2, const int8_t ms3) {
     if (ms1 >= 0) switch (driver) {
-      case 0: WRITE(X_MS1_PIN, ms1); break;
-      #if HAS_Y_MICROSTEPS
-        case 1: WRITE(Y_MS1_PIN, ms1); break;
+      #if HAS_X_MICROSTEPS || HAS_X2_MICROSTEPS
+        case 0:
+          #if HAS_X_MICROSTEPS
+            WRITE(X_MS1_PIN, ms1);
+          #endif
+          #if HAS_X2_MICROSTEPS
+            WRITE(X2_MS1_PIN, ms1);
+          #endif
+          break;
       #endif
-      #if HAS_Z_MICROSTEPS
-        case 2: WRITE(Z_MS1_PIN, ms1); break;
+      #if HAS_Y_MICROSTEPS || HAS_Y2_MICROSTEPS
+        case 1:
+          #if HAS_Y_MICROSTEPS
+            WRITE(Y_MS1_PIN, ms1);
+          #endif
+          #if HAS_Y2_MICROSTEPS
+            WRITE(Y2_MS1_PIN, ms1);
+          #endif
+          break;
+      #endif
+      #if HAS_Z_MICROSTEPS || HAS_Z2_MICROSTEPS || HAS_Z3_MICROSTEPS
+        case 2:
+          #if HAS_Z_MICROSTEPS
+            WRITE(Z_MS1_PIN, ms1);
+          #endif
+          #if HAS_Z2_MICROSTEPS
+            WRITE(Z2_MS1_PIN, ms1);
+          #endif
+          #if HAS_Z3_MICROSTEPS
+            WRITE(Z3_MS1_PIN, ms1);
+          #endif
+          break;
       #endif
       #if HAS_E0_MICROSTEPS
         case 3: WRITE(E0_MS1_PIN, ms1); break;
@@ -2572,12 +2655,38 @@ void Stepper::report_positions() {
       #endif
     }
     if (ms2 >= 0) switch (driver) {
-      case 0: WRITE(X_MS2_PIN, ms2); break;
-      #if HAS_Y_MICROSTEPS
-        case 1: WRITE(Y_MS2_PIN, ms2); break;
+      #if HAS_X_MICROSTEPS || HAS_X2_MICROSTEPS
+        case 0:
+          #if HAS_X_MICROSTEPS
+            WRITE(X_MS2_PIN, ms2);
+          #endif
+          #if HAS_X2_MICROSTEPS
+            WRITE(X2_MS2_PIN, ms2);
+          #endif
+          break;
       #endif
-      #if HAS_Z_MICROSTEPS
-        case 2: WRITE(Z_MS2_PIN, ms2); break;
+      #if HAS_Y_MICROSTEPS || HAS_Y2_MICROSTEPS
+        case 1:
+          #if HAS_Y_MICROSTEPS
+            WRITE(Y_MS2_PIN, ms2);
+          #endif
+          #if HAS_Y2_MICROSTEPS
+            WRITE(Y2_MS2_PIN, ms2);
+          #endif
+          break;
+      #endif
+      #if HAS_Z_MICROSTEPS || HAS_Z2_MICROSTEPS || HAS_Z3_MICROSTEPS
+        case 2:
+          #if HAS_Z_MICROSTEPS
+            WRITE(Z_MS2_PIN, ms2);
+          #endif
+          #if HAS_Z2_MICROSTEPS
+            WRITE(Z2_MS2_PIN, ms2);
+          #endif
+          #if HAS_Z3_MICROSTEPS
+            WRITE(Z3_MS2_PIN, ms2);
+          #endif
+          break;
       #endif
       #if HAS_E0_MICROSTEPS
         case 3: WRITE(E0_MS2_PIN, ms2); break;
@@ -2598,70 +2707,165 @@ void Stepper::report_positions() {
         case 8: WRITE(E5_MS2_PIN, ms2); break;
       #endif
     }
+    if (ms3 >= 0) switch (driver) {
+      #if HAS_X_MICROSTEPS || HAS_X2_MICROSTEPS
+        case 0:
+          #if HAS_X_MICROSTEPS && PIN_EXISTS(X_MS3)
+            WRITE(X_MS3_PIN, ms3);
+          #endif
+          #if HAS_X2_MICROSTEPS && PIN_EXISTS(X2_MS3)
+            WRITE(X2_MS3_PIN, ms3);
+          #endif
+          break;
+      #endif
+      #if HAS_Y_MICROSTEPS || HAS_Y2_MICROSTEPS
+        case 1:
+          #if HAS_Y_MICROSTEPS && PIN_EXISTS(Y_MS3)
+            WRITE(Y_MS3_PIN, ms3);
+          #endif
+          #if HAS_Y2_MICROSTEPS && PIN_EXISTS(Y2_MS3)
+            WRITE(Y2_MS3_PIN, ms3);
+          #endif
+          break;
+      #endif
+      #if HAS_Z_MICROSTEPS || HAS_Z2_MICROSTEPS || HAS_Z3_MICROSTEPS
+        case 2:
+          #if HAS_Z_MICROSTEPS && PIN_EXISTS(Z_MS3)
+            WRITE(Z_MS3_PIN, ms3);
+          #endif
+          #if HAS_Z2_MICROSTEPS && PIN_EXISTS(Z2_MS3)
+            WRITE(Z2_MS3_PIN, ms3);
+          #endif
+          #if HAS_Z3_MICROSTEPS && PIN_EXISTS(Z3_MS3)
+            WRITE(Z3_MS3_PIN, ms3);
+          #endif
+          break;
+      #endif
+      #if HAS_E0_MICROSTEPS && PIN_EXISTS(E0_MS3)
+        case 3: WRITE(E0_MS3_PIN, ms3); break;
+      #endif
+      #if HAS_E1_MICROSTEPS && PIN_EXISTS(E1_MS3)
+        case 4: WRITE(E1_MS3_PIN, ms3); break;
+      #endif
+      #if HAS_E2_MICROSTEPS && PIN_EXISTS(E2_MS3)
+        case 5: WRITE(E2_MS3_PIN, ms3); break;
+      #endif
+      #if HAS_E3_MICROSTEPS && PIN_EXISTS(E3_MS3)
+        case 6: WRITE(E3_MS3_PIN, ms3); break;
+      #endif
+      #if HAS_E4_MICROSTEPS && PIN_EXISTS(E4_MS3)
+        case 7: WRITE(E4_MS3_PIN, ms3); break;
+      #endif
+      #if HAS_E5_MICROSTEPS && PIN_EXISTS(E5_MS3)
+        case 8: WRITE(E5_MS3_PIN, ms3); break;
+      #endif    
+    }
   }
 
   void Stepper::microstep_mode(const uint8_t driver, const uint8_t stepping_mode) {
     switch (stepping_mode) {
-      case 1: microstep_ms(driver, MICROSTEP1); break;
-      #if ENABLED(HEROIC_STEPPER_DRIVERS)
-        case 128: microstep_ms(driver, MICROSTEP128); break;
-      #else
+      #if HAS_MICROSTEP1
+        case 1: microstep_ms(driver, MICROSTEP1); break;
+      #endif
+      #if HAS_MICROSTEP2
         case 2: microstep_ms(driver, MICROSTEP2); break;
+      #endif
+      #if HAS_MICROSTEP4
         case 4: microstep_ms(driver, MICROSTEP4); break;
       #endif
-      case 8: microstep_ms(driver, MICROSTEP8); break;
-      case 16: microstep_ms(driver, MICROSTEP16); break;
-      #if MB(ALLIGATOR)
+      #if HAS_MICROSTEP8
+        case 8: microstep_ms(driver, MICROSTEP8); break;
+      #endif
+      #if HAS_MICROSTEP16
+        case 16: microstep_ms(driver, MICROSTEP16); break;
+      #endif
+      #if HAS_MICROSTEP32
         case 32: microstep_ms(driver, MICROSTEP32); break;
       #endif
+      #if HAS_MICROSTEP64
+        case 64: microstep_ms(driver, MICROSTEP64); break;
+      #endif
+      #if HAS_MICROSTEP128
+        case 128: microstep_ms(driver, MICROSTEP128); break;
+      #endif
+
       default: SERIAL_ERROR_START(); SERIAL_ERRORLNPGM("Microsteps unavailable"); break;
     }
   }
 
   void Stepper::microstep_readings() {
-    SERIAL_PROTOCOLLNPGM("MS1,MS2 Pins");
+    SERIAL_PROTOCOLLNPGM("MS1,MS2,MS3 Pins");
     SERIAL_PROTOCOLPGM("X: ");
-    SERIAL_PROTOCOL(READ(X_MS1_PIN));
-    SERIAL_PROTOCOLLN(READ(X_MS2_PIN));
+    #if HAS_X_MICROSTEPS
+      SERIAL_PROTOCOL(READ(X_MS1_PIN));
+      SERIAL_PROTOCOL(READ(X_MS2_PIN));
+      #if PIN_EXISTS(X_MS3)
+        SERIAL_PROTOCOLLN(READ(X_MS3_PIN));
+      #endif
+    #endif
     #if HAS_Y_MICROSTEPS
       SERIAL_PROTOCOLPGM("Y: ");
       SERIAL_PROTOCOL(READ(Y_MS1_PIN));
-      SERIAL_PROTOCOLLN(READ(Y_MS2_PIN));
+      SERIAL_PROTOCOL(READ(Y_MS2_PIN));
+      #if PIN_EXISTS(Y_MS3)
+        SERIAL_PROTOCOLLN(READ(Y_MS3_PIN));
+      #endif
     #endif
     #if HAS_Z_MICROSTEPS
       SERIAL_PROTOCOLPGM("Z: ");
       SERIAL_PROTOCOL(READ(Z_MS1_PIN));
-      SERIAL_PROTOCOLLN(READ(Z_MS2_PIN));
+      SERIAL_PROTOCOL(READ(Z_MS2_PIN));
+      #if PIN_EXISTS(Z_MS3)
+        SERIAL_PROTOCOLLN(READ(Z_MS3_PIN));
+      #endif
     #endif
     #if HAS_E0_MICROSTEPS
       SERIAL_PROTOCOLPGM("E0: ");
       SERIAL_PROTOCOL(READ(E0_MS1_PIN));
-      SERIAL_PROTOCOLLN(READ(E0_MS2_PIN));
+      SERIAL_PROTOCOL(READ(E0_MS2_PIN));
+      #if PIN_EXISTS(E0_MS3)
+        SERIAL_PROTOCOLLN(READ(E0_MS3_PIN));
+      #endif
     #endif
     #if HAS_E1_MICROSTEPS
       SERIAL_PROTOCOLPGM("E1: ");
       SERIAL_PROTOCOL(READ(E1_MS1_PIN));
-      SERIAL_PROTOCOLLN(READ(E1_MS2_PIN));
+      SERIAL_PROTOCOL(READ(E1_MS2_PIN));
+      #if PIN_EXISTS(E1_MS3)
+        SERIAL_PROTOCOLLN(READ(E1_MS3_PIN));
+      #endif
     #endif
     #if HAS_E2_MICROSTEPS
       SERIAL_PROTOCOLPGM("E2: ");
       SERIAL_PROTOCOL(READ(E2_MS1_PIN));
-      SERIAL_PROTOCOLLN(READ(E2_MS2_PIN));
+      SERIAL_PROTOCOL(READ(E2_MS2_PIN));
+      #if PIN_EXISTS(E2_MS3)
+        SERIAL_PROTOCOLLN(READ(E2_MS3_PIN));
+      #endif
     #endif
     #if HAS_E3_MICROSTEPS
       SERIAL_PROTOCOLPGM("E3: ");
       SERIAL_PROTOCOL(READ(E3_MS1_PIN));
-      SERIAL_PROTOCOLLN(READ(E3_MS2_PIN));
+      SERIAL_PROTOCOL(READ(E3_MS2_PIN));
+      #if PIN_EXISTS(E3_MS3)
+        SERIAL_PROTOCOLLN(READ(E3_MS3_PIN));
+      #endif
     #endif
     #if HAS_E4_MICROSTEPS
       SERIAL_PROTOCOLPGM("E4: ");
       SERIAL_PROTOCOL(READ(E4_MS1_PIN));
-      SERIAL_PROTOCOLLN(READ(E4_MS2_PIN));
+      SERIAL_PROTOCOL(READ(E4_MS2_PIN));
+      #if PIN_EXISTS(E4_MS3)
+        SERIAL_PROTOCOLLN(READ(E4_MS3_PIN));
+      #endif
     #endif
     #if HAS_E5_MICROSTEPS
       SERIAL_PROTOCOLPGM("E5: ");
       SERIAL_PROTOCOL(READ(E5_MS1_PIN));
       SERIAL_PROTOCOLLN(READ(E5_MS2_PIN));
+      #if PIN_EXISTS(E5_MS3)
+        SERIAL_PROTOCOLLN(READ(E5_MS3_PIN));
+      #endif      
     #endif
   }
 
diff --git a/Marlin/src/module/stepper.h b/Marlin/src/module/stepper.h
index 0ebe1d6e2..95f28dc91 100644
--- a/Marlin/src/module/stepper.h
+++ b/Marlin/src/module/stepper.h
@@ -413,7 +413,7 @@ class Stepper {
     #endif
 
     #if HAS_MICROSTEPS
-      static void microstep_ms(const uint8_t driver, const int8_t ms1, const int8_t ms2);
+      static void microstep_ms(const uint8_t driver, const int8_t ms1, const int8_t ms2, const int8_t ms3);
       static void microstep_mode(const uint8_t driver, const uint8_t stepping);
       static void microstep_readings();
     #endif
diff --git a/Marlin/src/pins/pins.h b/Marlin/src/pins/pins.h
index 81eacf5df..e8d9f4a7c 100644
--- a/Marlin/src/pins/pins.h
+++ b/Marlin/src/pins/pins.h
@@ -19,6 +19,7 @@
  * along with this program.  If not, see <http://www.gnu.org/licenses/>.
  *
  */
+#pragma once
 
 /**
  * Include pins definitions
@@ -32,9 +33,6 @@
  *    These numbers are the same in any pin mapping.
  */
 
-#ifndef __PINS_H__
-#define __PINS_H__
-
 #define MAX_EXTRUDERS 6
 
 #if MB(RAMPS_13_EFB) || MB(RAMPS_14_EFB) || MB(RAMPS_PLUS_EFB) || MB(RAMPS_14_RE_ARM_EFB) || MB(RAMPS_SMART_EFB) || MB(RAMPS_DUO_EFB) || MB(RAMPS4DUE_EFB)
@@ -427,12 +425,18 @@
 #ifndef X_MS2_PIN
   #define X_MS2_PIN -1
 #endif
+#ifndef X_MS3_PIN
+  #define X_MS3_PIN -1
+#endif
 #ifndef Y_MS1_PIN
   #define Y_MS1_PIN -1
 #endif
 #ifndef Y_MS2_PIN
   #define Y_MS2_PIN -1
 #endif
+#ifndef Y_MS3_PIN
+  #define Y_MS3_PIN -1
+#endif
 #ifndef Z_MS1_PIN
   #define Z_MS1_PIN -1
 #endif
@@ -448,18 +452,27 @@
 #ifndef E0_MS2_PIN
   #define E0_MS2_PIN -1
 #endif
+#ifndef E0_MS3_PIN
+  #define E0_MS3_PIN -1
+#endif
 #ifndef E1_MS1_PIN
   #define E1_MS1_PIN -1
 #endif
 #ifndef E1_MS2_PIN
   #define E1_MS2_PIN -1
 #endif
+#ifndef E1_MS3_PIN
+  #define E1_MS3_PIN -1
+#endif
 #ifndef E2_MS1_PIN
   #define E2_MS1_PIN -1
 #endif
 #ifndef E2_MS2_PIN
   #define E2_MS2_PIN -1
 #endif
+#ifndef E2_MS3_PIN
+  #define E2_MS3_PIN -1
+#endif
 #ifndef E3_MS1_PIN
   #define E3_MS1_PIN -1
 #endif
@@ -650,7 +663,8 @@
 #ifndef LED_PIN
   #define LED_PIN -1
 #endif
-#ifndef PS_ON_PIN
+#if POWER_SUPPLY == 0 || !defined(PS_ON_PIN)
+  #undef PS_ON_PIN
   #define PS_ON_PIN -1
 #endif
 #ifndef KILL_PIN
@@ -717,94 +731,6 @@
   #endif
 #endif
 
-// List of pins which to ignore when asked to change by gcode, 0 and 1 are RX and TX, do not mess with those!
-#define _E0_PINS E0_STEP_PIN, E0_DIR_PIN, E0_ENABLE_PIN, E0_MS1_PIN, E0_MS2_PIN, E0_CS_PIN,
-#define _E1_PINS
-#define _E2_PINS
-#define _E3_PINS
-#define _E4_PINS
-#define _E5_PINS
-
-#if ENABLED(SWITCHING_EXTRUDER)
-                      // Tools 0 and 1 use E0
-  #if EXTRUDERS > 2   // Tools 2 and 3 use E1
-    #undef _E1_PINS
-    #define _E1_PINS E1_STEP_PIN, E1_DIR_PIN, E1_ENABLE_PIN, E1_MS1_PIN, E1_MS2_PIN, E1_CS_PIN,
-    #if EXTRUDERS > 4 // Tools 4 and 5 use E2
-      #undef _E2_PINS
-      #define _E2_PINS E2_STEP_PIN, E2_DIR_PIN, E2_ENABLE_PIN, E2_MS1_PIN, E2_MS2_PIN, E2_CS_PIN,
-    #endif
-  #endif
-#elif EXTRUDERS > 1
-  #undef _E1_PINS
-  #define _E1_PINS E1_STEP_PIN, E1_DIR_PIN, E1_ENABLE_PIN, E1_MS1_PIN, E1_MS2_PIN, E1_CS_PIN,
-  #if EXTRUDERS > 2
-    #undef _E2_PINS
-    #define _E2_PINS E2_STEP_PIN, E2_DIR_PIN, E2_ENABLE_PIN, E2_MS1_PIN, E2_MS2_PIN, E2_CS_PIN,
-    #if EXTRUDERS > 3
-      #undef _E3_PINS
-      #define _E3_PINS E3_STEP_PIN, E3_DIR_PIN, E3_ENABLE_PIN, E3_MS1_PIN, E3_MS2_PIN, E3_MS3_PIN, E3_CS_PIN,
-      #if EXTRUDERS > 4
-        #undef _E4_PINS
-        #define _E4_PINS E4_STEP_PIN, E4_DIR_PIN, E4_ENABLE_PIN, E4_MS1_PIN, E4_MS2_PIN, E4_MS3_PIN, E4_CS_PIN,
-        #if EXTRUDERS > 5
-          #undef _E5_PINS
-          #define _E5_PINS E5_STEP_PIN, E5_DIR_PIN, E5_ENABLE_PIN, E5_MS1_PIN, E5_MS2_PIN, E5_MS3_PIN, E5_CS_PIN,
-        #endif // EXTRUDERS > 5
-      #endif // EXTRUDERS > 4
-    #endif // EXTRUDERS > 3
-  #endif // EXTRUDERS > 2
-#endif // EXTRUDERS > 1
-
-#define _H0_PINS HEATER_0_PIN, E0_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_0_PIN),
-#define _H1_PINS
-#define _H2_PINS
-#define _H3_PINS
-#define _H4_PINS
-#define _H5_PINS
-
-#if HOTENDS > 1
-  #undef _H1_PINS
-  #define _H1_PINS HEATER_1_PIN, E1_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_1_PIN),
-  #if HOTENDS > 2
-    #undef _H2_PINS
-    #define _H2_PINS HEATER_2_PIN, E2_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_2_PIN),
-    #if HOTENDS > 3
-      #undef _H3_PINS
-      #define _H3_PINS HEATER_3_PIN, E3_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_3_PIN),
-      #if HOTENDS > 4
-        #undef _H4_PINS
-        #define _H4_PINS HEATER_4_PIN, E4_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_4_PIN),
-        #if HOTENDS > 5
-          #undef _H5_PINS
-          #define _H5_PINS HEATER_5_PIN, E5_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_5_PIN),
-        #endif // HOTENDS > 5
-      #endif // HOTENDS > 4
-    #endif // HOTENDS > 3
-  #endif // HOTENDS > 2
-#elif ENABLED(MIXING_EXTRUDER)
-  #undef _E1_PINS
-  #define _E1_PINS E1_STEP_PIN, E1_DIR_PIN, E1_ENABLE_PIN, E1_MS1_PIN, E1_MS2_PIN, E1_CS_PIN,
-  #if MIXING_STEPPERS > 2
-    #undef _E2_PINS
-    #define _E2_PINS E2_STEP_PIN, E2_DIR_PIN, E2_ENABLE_PIN, E2_MS1_PIN, E2_MS2_PIN, E2_CS_PIN,
-    #if MIXING_STEPPERS > 3
-      #undef _E3_PINS
-      #define _E3_PINS E3_STEP_PIN, E3_DIR_PIN, E3_ENABLE_PIN, E3_MS1_PIN, E3_MS2_PIN, E3_CS_PIN,
-      #if MIXING_STEPPERS > 4
-        #undef _E4_PINS
-        #define _E4_PINS E4_STEP_PIN, E4_DIR_PIN, E4_ENABLE_PIN, E4_MS1_PIN, E4_MS2_PIN, E4_CS_PIN,
-        #if MIXING_STEPPERS > 5
-          #undef _E5_PINS
-          #define _E5_PINS E5_STEP_PIN, E5_DIR_PIN, E5_ENABLE_PIN, E5_MS1_PIN, E5_MS2_PIN, E5_CS_PIN,
-        #endif // MIXING_STEPPERS > 5
-      #endif // MIXING_STEPPERS > 4
-    #endif // MIXING_STEPPERS > 3
-  #endif // MIXING_STEPPERS > 2
-#endif // MIXING_STEPPERS > 1
-
-#define BED_PINS HEATER_BED_PIN, analogInputToDigitalPin(TEMP_BED_PIN),
-
 //
 // Assign endstop pins for boards with only 3 connectors
 //
@@ -841,7 +767,7 @@
 //
 // Disable unused endstop / probe pins
 //
-#if DISABLED(Z_MIN_PROBE_ENDSTOP)
+#if !HAS_BED_PROBE || DISABLED(Z_MIN_PROBE_ENDSTOP)
   #undef Z_MIN_PROBE_PIN
   #define Z_MIN_PROBE_PIN    -1
 #endif
@@ -889,14 +815,13 @@
   #define LCD_PINS_D7 -1
 #endif
 
-//
-// Dual X-carriage, Dual Y, Dual Z support
-//
-
-#define _X2_PINS
-#define _Y2_PINS
-#define _Z2_PINS
-#define _Z3_PINS
+/**
+ * Auto-Assignment for Dual X, Dual Y, Multi-Z Steppers
+ *
+ * By default X2 is assigned to the next open E plug
+ * on the board, then in order, Y2, Z2, Z3. These can be
+ * overridden in Configuration.h or Configuration_adv.h.
+ */
 
 #define __EPIN(p,q) E##p##_##q##_PIN
 #define _EPIN(p,q) __EPIN(p,q)
@@ -907,19 +832,21 @@
     #define X2_STEP_PIN   _EPIN(E_STEPPERS, STEP)
     #define X2_DIR_PIN    _EPIN(E_STEPPERS, DIR)
     #define X2_ENABLE_PIN _EPIN(E_STEPPERS, ENABLE)
-    #ifndef X2_CS_PIN
-      #define X2_CS_PIN   _EPIN(E_STEPPERS, CS)
-    #endif
-    #if E_STEPPERS > MAX_EXTRUDERS || !PIN_EXISTS(X2_ENABLE)
+    #if E_STEPPERS >= MAX_EXTRUDERS || !PIN_EXISTS(X2_STEP)
       #error "No E stepper plug left for X2!"
     #endif
   #endif
-  #undef _X2_PINS
-  #define __X2_PINS X2_STEP_PIN, X2_DIR_PIN, X2_ENABLE_PIN,
-  #ifdef X2_CS_PIN
-    #define _X2_PINS __X2_PINS X2_CS_PIN,
-  #else
-    #define _X2_PINS __X2_PINS
+  #ifndef X2_CS_PIN
+    #define X2_CS_PIN     _EPIN(E_STEPPERS, CS)
+  #endif
+  #ifndef X2_MS1_PIN
+    #define X2_MS1_PIN    _EPIN(E_STEPPERS, MS1)
+  #endif
+  #ifndef X2_MS2_PIN
+    #define X2_MS2_PIN    _EPIN(E_STEPPERS, MS2)
+  #endif
+  #ifndef X2_MS3_PIN
+    #define X2_MS3_PIN    _EPIN(E_STEPPERS, MS3)
   #endif
   #define Y2_E_INDEX INCREMENT(E_STEPPERS)
 #else
@@ -932,19 +859,21 @@
     #define Y2_STEP_PIN   _EPIN(Y2_E_INDEX, STEP)
     #define Y2_DIR_PIN    _EPIN(Y2_E_INDEX, DIR)
     #define Y2_ENABLE_PIN _EPIN(Y2_E_INDEX, ENABLE)
-    #ifndef Y2_CS_PIN
-      #define Y2_CS_PIN   _EPIN(Y2_E_INDEX, CS)
-    #endif
-    #if Y2_E_INDEX > MAX_EXTRUDERS || !PIN_EXISTS(Y2_ENABLE)
+    #if Y2_E_INDEX >= MAX_EXTRUDERS || !PIN_EXISTS(Y2_STEP)
       #error "No E stepper plug left for Y2!"
     #endif
   #endif
-  #undef _Y2_PINS
-  #define __Y2_PINS Y2_STEP_PIN, Y2_DIR_PIN, Y2_ENABLE_PIN,
-  #ifdef Y2_CS_PIN
-    #define _Y2_PINS __Y2_PINS Y2_CS_PIN,
-  #else
-    #define _Y2_PINS __Y2_PINS
+  #ifndef Y2_CS_PIN
+    #define Y2_CS_PIN     _EPIN(Y2_E_INDEX, CS)
+  #endif
+  #ifndef Y2_MS1_PIN
+    #define Y2_MS1_PIN    _EPIN(Y2_E_INDEX, MS1)
+  #endif
+  #ifndef Y2_MS2_PIN
+    #define Y2_MS2_PIN    _EPIN(Y2_E_INDEX, MS2)
+  #endif
+  #ifndef Y2_MS3_PIN
+    #define Y2_MS3_PIN    _EPIN(Y2_E_INDEX, MS3)
   #endif
   #define Z2_E_INDEX INCREMENT(Y2_E_INDEX)
 #else
@@ -957,19 +886,21 @@
     #define Z2_STEP_PIN   _EPIN(Z2_E_INDEX, STEP)
     #define Z2_DIR_PIN    _EPIN(Z2_E_INDEX, DIR)
     #define Z2_ENABLE_PIN _EPIN(Z2_E_INDEX, ENABLE)
-    #ifndef Z2_CS_PIN
-      #define Z2_CS_PIN   _EPIN(Z2_E_INDEX, CS)
-    #endif
-    #if Z2_E_INDEX > MAX_EXTRUDERS || !PIN_EXISTS(Z2_ENABLE)
+    #if Z2_E_INDEX >= MAX_EXTRUDERS || !PIN_EXISTS(Z2_STEP)
       #error "No E stepper plug left for Z2!"
     #endif
   #endif
-  #undef _Z2_PINS
-  #define __Z2_PINS Z2_STEP_PIN, Z2_DIR_PIN, Z2_ENABLE_PIN,
-  #ifdef Z2_CS_PIN
-    #define _Z2_PINS __Z2_PINS Z2_CS_PIN,
-  #else
-    #define _Z2_PINS __Z2_PINS
+  #ifndef Z2_CS_PIN
+    #define Z2_CS_PIN     _EPIN(Z2_E_INDEX, CS)
+  #endif
+  #ifndef Z2_MS1_PIN
+    #define Z2_MS1_PIN    _EPIN(Z2_E_INDEX, MS1)
+  #endif
+  #ifndef Z2_MS2_PIN
+    #define Z2_MS2_PIN    _EPIN(Z2_E_INDEX, MS2)
+  #endif
+  #ifndef Z2_MS3_PIN
+    #define Z2_MS3_PIN    _EPIN(Z2_E_INDEX, MS3)
   #endif
   #define Z3_E_INDEX INCREMENT(Z2_E_INDEX)
 #else
@@ -981,41 +912,20 @@
     #define Z3_STEP_PIN   _EPIN(Z3_E_INDEX, STEP)
     #define Z3_DIR_PIN    _EPIN(Z3_E_INDEX, DIR)
     #define Z3_ENABLE_PIN _EPIN(Z3_E_INDEX, ENABLE)
-    #ifndef Z3_CS_PIN
-      #define Z3_CS_PIN   _EPIN(Z3_E_INDEX, CS)
-    #endif
-    #if Z3_E_INDEX > 4 || !PIN_EXISTS(Z3_ENABLE)
+    #if Z3_E_INDEX >= MAX_EXTRUDERS || !PIN_EXISTS(Z3_STEP)
       #error "No E stepper plug left for Z3!"
     #endif
   #endif
-  #undef _Z3_PINS
-  #define __Z3_PINS Z3_STEP_PIN, Z3_DIR_PIN, Z3_ENABLE_PIN,
-  #ifdef Z3_CS_PIN
-    #define _Z3_PINS __Z3_PINS Z3_CS_PIN,
-  #else
-    #define _Z3_PINS __Z3_PINS
+  #ifndef Z3_CS_PIN
+    #define Z3_CS_PIN     _EPIN(Z3_E_INDEX, CS)
+  #endif
+  #ifndef Z3_MS1_PIN
+    #define Z3_MS1_PIN    _EPIN(Z3_E_INDEX, MS1)
+  #endif
+  #ifndef Z3_MS2_PIN
+    #define Z3_MS2_PIN    _EPIN(Z3_E_INDEX, MS2)
+  #endif
+  #ifndef Z3_MS3_PIN
+    #define Z3_MS3_PIN    _EPIN(Z3_E_INDEX, MS3)
   #endif
 #endif
-
-#ifndef HAL_SENSITIVE_PINS
-  #define HAL_SENSITIVE_PINS
-#endif
-
-#define SENSITIVE_PINS { \
-    X_STEP_PIN, X_DIR_PIN, X_ENABLE_PIN, X_MIN_PIN, X_MAX_PIN, X_MS1_PIN, X_MS2_PIN, X_CS_PIN, \
-    Y_STEP_PIN, Y_DIR_PIN, Y_ENABLE_PIN, Y_MIN_PIN, Y_MAX_PIN, Y_MS1_PIN, Y_MS2_PIN, Y_CS_PIN, \
-    Z_STEP_PIN, Z_DIR_PIN, Z_ENABLE_PIN, Z_MIN_PIN, Z_MAX_PIN, Z_MS1_PIN, Z_MS2_PIN, Z_MS3_PIN, Z_CS_PIN, Z_MIN_PROBE_PIN, \
-    PS_ON_PIN, HEATER_BED_PIN, FAN_PIN, FAN1_PIN, FAN2_PIN, CONTROLLER_FAN_PIN, \
-    _E0_PINS _E1_PINS _E2_PINS _E3_PINS _E4_PINS _E5_PINS BED_PINS \
-    _H0_PINS _H1_PINS _H2_PINS _H3_PINS _H4_PINS _H5_PINS \
-    _X2_PINS _Y2_PINS _Z2_PINS _Z3_PINS \
-    HAL_SENSITIVE_PINS \
-  }
-
-#define HAS_DIGIPOTSS (PIN_EXISTS(DIGIPOTSS))
-
-// Note: default SPI pins are defined in the HAL
-
-#include HAL_PATH(../HAL, spi_pins.h)
-
-#endif // __PINS_H__
diff --git a/Marlin/src/pins/pinsDebug_list.h b/Marlin/src/pins/pinsDebug_list.h
index e6ac174c1..df4e16329 100644
--- a/Marlin/src/pins/pinsDebug_list.h
+++ b/Marlin/src/pins/pinsDebug_list.h
@@ -268,6 +268,9 @@
 #if PIN_EXISTS(E0_MS2)
   REPORT_NAME_DIGITAL(__LINE__, E0_MS2_PIN)
 #endif
+#if PIN_EXISTS(E0_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, E0_MS3_PIN)
+#endif
 #if PIN_EXISTS(E0_STEP)
   REPORT_NAME_DIGITAL(__LINE__, E0_STEP_PIN)
 #endif
@@ -289,6 +292,9 @@
 #if PIN_EXISTS(E1_MS2)
   REPORT_NAME_DIGITAL(__LINE__, E1_MS2_PIN)
 #endif
+#if PIN_EXISTS(E1_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, E1_MS3_PIN)
+#endif
 #if PIN_EXISTS(E1_STEP)
   REPORT_NAME_DIGITAL(__LINE__, E1_STEP_PIN)
 #endif
@@ -310,6 +316,9 @@
 #if PIN_EXISTS(E2_MS2)
   REPORT_NAME_DIGITAL(__LINE__, E2_MS2_PIN)
 #endif
+#if PIN_EXISTS(E2_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, E2_MS3_PIN)
+#endif
 #if PIN_EXISTS(E2_STEP)
   REPORT_NAME_DIGITAL(__LINE__, E2_STEP_PIN)
 #endif
@@ -881,6 +890,9 @@
 #if PIN_EXISTS(X_MS2)
   REPORT_NAME_DIGITAL(__LINE__, X_MS2_PIN)
 #endif
+#if PIN_EXISTS(X_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, X_MS3_PIN)
+#endif
 #if PIN_EXISTS(X_STEP)
   REPORT_NAME_DIGITAL(__LINE__, X_STEP_PIN)
 #endif
@@ -893,6 +905,15 @@
 #if PIN_EXISTS(X2_ENABLE)
   REPORT_NAME_DIGITAL(__LINE__, X2_ENABLE_PIN)
 #endif
+#if PIN_EXISTS(X2_MS1)
+  REPORT_NAME_DIGITAL(__LINE__, X2_MS1_PIN)
+#endif
+#if PIN_EXISTS(X2_MS2)
+  REPORT_NAME_DIGITAL(__LINE__, X2_MS2_PIN)
+#endif
+#if PIN_EXISTS(X2_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, X2_MS3_PIN)
+#endif
 #if PIN_EXISTS(X2_STEP)
   REPORT_NAME_DIGITAL(__LINE__, X2_STEP_PIN)
 #endif
@@ -920,6 +941,9 @@
 #if PIN_EXISTS(Y_MS2)
   REPORT_NAME_DIGITAL(__LINE__, Y_MS2_PIN)
 #endif
+#if PIN_EXISTS(Y_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, Y_MS3_PIN)
+#endif
 #if PIN_EXISTS(Y_STEP)
   REPORT_NAME_DIGITAL(__LINE__, Y_STEP_PIN)
 #endif
@@ -932,6 +956,15 @@
 #if PIN_EXISTS(Y2_ENABLE)
   REPORT_NAME_DIGITAL(__LINE__, Y2_ENABLE_PIN)
 #endif
+#if PIN_EXISTS(Y2_MS1)
+  REPORT_NAME_DIGITAL(__LINE__, Y2_MS1_PIN)
+#endif
+#if PIN_EXISTS(Y2_MS2)
+  REPORT_NAME_DIGITAL(__LINE__, Y2_MS2_PIN)
+#endif
+#if PIN_EXISTS(Y2_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, Y2_MS3_PIN)
+#endif
 #if PIN_EXISTS(Y2_STEP)
   REPORT_NAME_DIGITAL(__LINE__, Y2_STEP_PIN)
 #endif
@@ -962,6 +995,9 @@
 #if PIN_EXISTS(Z_MS2)
   REPORT_NAME_DIGITAL(__LINE__, Z_MS2_PIN)
 #endif
+#if PIN_EXISTS(Z_MS3)
+  REPORT_NAME_DIGITAL(__LINE__, Z_MS3_PIN)
+#endif
 #if PIN_EXISTS(Z_STEP)
   REPORT_NAME_DIGITAL(__LINE__, Z_STEP_PIN)
 #endif
diff --git a/Marlin/src/pins/pins_RURAMPS4D_11.h b/Marlin/src/pins/pins_RURAMPS4D_11.h
index d05b74b04..7b78ffc7b 100644
--- a/Marlin/src/pins/pins_RURAMPS4D_11.h
+++ b/Marlin/src/pins/pins_RURAMPS4D_11.h
@@ -119,9 +119,6 @@
 //#define E3_MS1_PIN         ?
 //#define E3_MS2_PIN         ?
 //#define E3_MS3_PIN         ?
-//#define Z2_MS1_PIN         ?   // shared with E3_MS1_PIN
-//#define Z2_MS2_PIN         ?   // shared with E3_MS2_PIN
-//#define Z2_MS3_PIN         ?   // shared with E3_MS3_PIN
 
 #if DISABLED(Z_MIN_PROBE_USES_Z_MIN_ENDSTOP_PIN)
   #define Z_MIN_PROBE_PIN  49
diff --git a/Marlin/src/pins/sensitive_pins.h b/Marlin/src/pins/sensitive_pins.h
new file mode 100644
index 000000000..8b885bb0b
--- /dev/null
+++ b/Marlin/src/pins/sensitive_pins.h
@@ -0,0 +1,516 @@
+/**
+ * Marlin 3D Printer Firmware
+ * Copyright (C) 2016 MarlinFirmware [https://github.com/MarlinFirmware/Marlin]
+ *
+ * Based on Sprinter and grbl.
+ * Copyright (C) 2011 Camiel Gubbels / Erik van der Zalm
+ *
+ * This program is free software: you can redistribute it and/or modify
+ * it under the terms of the GNU General Public License as published by
+ * the Free Software Foundation, either version 3 of the License, or
+ * (at your option) any later version.
+ *
+ * This program is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+ * GNU General Public License for more details.
+ *
+ * You should have received a copy of the GNU General Public License
+ * along with this program.  If not, see <http://www.gnu.org/licenses/>.
+ *
+ */
+#pragma once
+
+//
+// Prepare a list of protected pins for M42/M43
+//
+
+#if PIN_EXISTS(X_MIN)
+  #define _X_MIN X_MIN_PIN,
+#else
+  #define _X_MIN
+#endif
+#if PIN_EXISTS(X_MAX)
+  #define _X_MAX X_MAX_PIN,
+#else
+  #define _X_MAX
+#endif
+#if PIN_EXISTS(X_CS)
+  #define _X_CS X_CS_PIN,
+#else
+  #define _X_CS
+#endif
+#if PIN_EXISTS(X_MS1)
+  #define _X_MS1 X_MS1_PIN,
+#else
+  #define _X_MS1
+#endif
+#if PIN_EXISTS(X_MS2)
+  #define _X_MS2 X_MS2_PIN,
+#else
+  #define _X_MS2
+#endif
+#if PIN_EXISTS(X_MS3)
+  #define _X_MS3 X_MS3_PIN,
+#else
+  #define _X_MS3
+#endif
+
+#define _X_PINS X_STEP_PIN, X_DIR_PIN, X_ENABLE_PIN, _X_MIN _X_MAX _X_MS1 _X_MS2 _X_MS3 _X_CS
+
+#if PIN_EXISTS(Y_MIN)
+  #define _Y_MIN Y_MIN_PIN,
+#else
+  #define _Y_MIN
+#endif
+#if PIN_EXISTS(Y_MAX)
+  #define _Y_MAX Y_MAX_PIN,
+#else
+  #define _Y_MAX
+#endif
+#if PIN_EXISTS(Y_CS)
+  #define _Y_CS Y_CS_PIN,
+#else
+  #define _Y_CS
+#endif
+#if PIN_EXISTS(Y_MS1)
+  #define _Y_MS1 Y_MS1_PIN,
+#else
+  #define _Y_MS1
+#endif
+#if PIN_EXISTS(Y_MS2)
+  #define _Y_MS2 Y_MS2_PIN,
+#else
+  #define _Y_MS2
+#endif
+#if PIN_EXISTS(Y_MS3)
+  #define _Y_MS3 Y_MS3_PIN,
+#else
+  #define _Y_MS3
+#endif
+
+#define _Y_PINS Y_STEP_PIN, Y_DIR_PIN, Y_ENABLE_PIN, _Y_MIN _Y_MAX _Y_MS1 _Y_MS2 _Y_MS3 _Y_CS
+
+#if PIN_EXISTS(Z_MIN)
+  #define _Z_MIN Z_MIN_PIN,
+#else
+  #define _Z_MIN
+#endif
+#if PIN_EXISTS(Z_MAX)
+  #define _Z_MAX Z_MAX_PIN,
+#else
+  #define _Z_MAX
+#endif
+#if PIN_EXISTS(Z_CS)
+  #define _Z_CS Z_CS_PIN,
+#else
+  #define _Z_CS
+#endif
+#if PIN_EXISTS(Z_MS1)
+  #define _Z_MS1 Z_MS1_PIN,
+#else
+  #define _Z_MS1
+#endif
+#if PIN_EXISTS(Z_MS2)
+  #define _Z_MS2 Z_MS2_PIN,
+#else
+  #define _Z_MS2
+#endif
+#if PIN_EXISTS(Z_MS3)
+  #define _Z_MS3 Z_MS3_PIN,
+#else
+  #define _Z_MS3
+#endif
+
+#define _Z_PINS Z_STEP_PIN, Z_DIR_PIN, Z_ENABLE_PIN, _Z_MIN _Z_MAX _Z_MS1 _Z_MS2 _Z_MS3 _Z_CS
+
+//
+// Extruder Chip Select, Digital Micro-steps
+//
+
+// Mixing stepper, Switching stepper, or regular stepper
+#define E_NEEDED(N) (ENABLED(MIXING_EXTRUDER) && MIXING_STEPPERS > N) \
+                 || (ENABLED(SWITCHING_EXTRUDER) && E_STEPPERS > N) \
+                 || (DISABLED(SWITCHING_EXTRUDER) && DISABLED(MIXING_EXTRUDER) && EXTRUDERS > N)
+
+#if PIN_EXISTS(E0_CS)
+  #define _E0_CS E0_CS_PIN,
+#else
+  #define _E0_CS
+#endif
+#if PIN_EXISTS(E0_MS1)
+  #define _E0_MS1 E0_MS1_PIN,
+#else
+  #define _E0_MS1
+#endif
+#if PIN_EXISTS(E0_MS2)
+  #define _E0_MS2 E0_MS2_PIN,
+#else
+  #define _E0_MS2
+#endif
+#if PIN_EXISTS(E0_MS3)
+  #define _E0_MS3 E0_MS3_PIN,
+#else
+  #define _E0_MS3
+#endif
+
+#define _E1_CS
+#define _E1_MS1
+#define _E1_MS2
+#define _E1_MS3
+
+#if E_NEEDED(1)
+  #if PIN_EXISTS(E1_CS)
+    #undef _E1_CS
+    #define _E1_CS E1_CS_PIN,
+  #endif
+  #if PIN_EXISTS(E1_MS1)
+    #undef _E1_MS1
+    #define _E1_MS1 E1_MS1_PIN,
+  #endif
+  #if PIN_EXISTS(E1_MS2)
+    #undef _E1_MS2
+    #define _E1_MS2 E1_MS2_PIN,
+  #endif
+  #if PIN_EXISTS(E1_MS3)
+    #undef _E1_MS3
+    #define _E1_MS3 E1_MS3_PIN,
+  #endif
+#endif
+
+#define _E2_CS
+#define _E2_MS1
+#define _E2_MS2
+#define _E2_MS3
+
+#if E_NEEDED(2)
+  #if PIN_EXISTS(E2_CS)
+    #undef _E2_CS
+    #define _E2_CS E2_CS_PIN,
+  #endif
+  #if PIN_EXISTS(E2_MS1)
+    #undef _E2_MS1
+    #define _E2_MS1 E2_MS1_PIN,
+  #endif
+  #if PIN_EXISTS(E2_MS2)
+    #undef _E2_MS2
+    #define _E2_MS2 E2_MS2_PIN,
+  #endif
+  #if PIN_EXISTS(E2_MS3)
+    #undef _E2_MS3
+    #define _E2_MS3 E2_MS3_PIN,
+  #endif
+#endif
+
+#define _E3_CS
+#define _E3_MS1
+#define _E3_MS2
+#define _E3_MS3
+
+#if E_NEEDED(3)
+  #if PIN_EXISTS(E3_CS)
+    #undef _E3_CS
+    #define _E3_CS E3_CS_PIN,
+  #endif
+  #if PIN_EXISTS(E3_MS1)
+    #undef _E3_MS1
+    #define _E3_MS1 E3_MS1_PIN,
+  #endif
+  #if PIN_EXISTS(E3_MS2)
+    #undef _E3_MS2
+    #define _E3_MS2 E3_MS2_PIN,
+  #endif
+  #if PIN_EXISTS(E3_MS3)
+    #undef _E3_MS3
+    #define _E3_MS3 E3_MS3_PIN,
+  #endif
+#endif
+
+#define _E4_CS
+#define _E4_MS1
+#define _E4_MS2
+#define _E4_MS3
+
+#if E_NEEDED(4)
+  #if PIN_EXISTS(E4_CS)
+    #undef _E4_CS
+    #define _E4_CS E4_CS_PIN,
+  #endif
+  #if PIN_EXISTS(E4_MS1)
+    #undef _E4_MS1
+    #define _E4_MS1 E4_MS1_PIN,
+  #endif
+  #if PIN_EXISTS(E4_MS2)
+    #undef _E4_MS2
+    #define _E4_MS2 E4_MS2_PIN,
+  #endif
+  #if PIN_EXISTS(E4_MS3)
+    #undef _E4_MS3
+    #define _E4_MS3 E4_MS3_PIN,
+  #endif
+#endif
+
+#define _E5_CS
+#define _E5_MS1
+#define _E5_MS2
+#define _E5_MS3
+
+#if E_NEEDED(5)
+  #if PIN_EXISTS(E5_CS)
+    #undef _E5_CS
+    #define _E5_CS E5_CS_PIN,
+  #endif
+  #if PIN_EXISTS(E5_MS1)
+    #undef _E5_MS1
+    #define _E5_MS1 E5_MS1_PIN,
+  #endif
+  #if PIN_EXISTS(E5_MS2)
+    #undef _E5_MS2
+    #define _E5_MS2 E5_MS2_PIN,
+  #endif
+  #if PIN_EXISTS(E5_MS3)
+    #undef _E5_MS3
+    #define _E5_MS3 E5_MS3_PIN,
+  #endif
+#endif
+
+//
+// E Steppers
+//
+
+#define _E0_PINS E0_STEP_PIN, E0_DIR_PIN, E0_ENABLE_PIN, _E0_CS _E0_MS1 _E0_MS2 _E0_MS3
+#define _E1_PINS
+#define _E2_PINS
+#define _E3_PINS
+#define _E4_PINS
+#define _E5_PINS
+
+#if ENABLED(SWITCHING_EXTRUDER)
+                      // Tools 0 and 1 use E0
+  #if EXTRUDERS > 2   // Tools 2 and 3 use E1
+    #undef _E1_PINS
+    #define _E1_PINS E1_STEP_PIN, E1_DIR_PIN, E1_ENABLE_PIN, _E1_CS _E1_MS1 _E1_MS2 _E1_MS3
+    #if EXTRUDERS > 4 // Tools 4 and 5 use E2
+      #undef _E2_PINS
+      #define _E2_PINS E2_STEP_PIN, E2_DIR_PIN, E2_ENABLE_PIN, _E2_CS _E2_MS1 _E2_MS2 _E2_MS3
+    #endif
+  #endif
+#elif EXTRUDERS > 1 || ENABLED(MIXING_EXTRUDER)
+  #undef _E1_PINS
+  #define _E1_PINS E1_STEP_PIN, E1_DIR_PIN, E1_ENABLE_PIN, _E1_CS _E1_MS1 _E1_MS2 _E1_MS3
+  #if EXTRUDERS > 2 || (ENABLED(MIXING_EXTRUDER) && MIXING_STEPPERS > 2)
+    #undef _E2_PINS
+    #define _E2_PINS E2_STEP_PIN, E2_DIR_PIN, E2_ENABLE_PIN, _E2_CS _E2_MS1 _E2_MS2 _E2_MS3
+    #if EXTRUDERS > 3 || (ENABLED(MIXING_EXTRUDER) && MIXING_STEPPERS > 3)
+      #undef _E3_PINS
+      #define _E3_PINS E3_STEP_PIN, E3_DIR_PIN, E3_ENABLE_PIN, _E3_CS _E3_MS1 _E3_MS2 _E3_MS3
+      #if EXTRUDERS > 4 || (ENABLED(MIXING_EXTRUDER) && MIXING_STEPPERS > 4)
+        #undef _E4_PINS
+        #define _E4_PINS E4_STEP_PIN, E4_DIR_PIN, E4_ENABLE_PIN, _E4_CS _E4_MS1 _E4_MS2 _E4_MS3
+        #if EXTRUDERS > 5 || (ENABLED(MIXING_EXTRUDER) && MIXING_STEPPERS > 5)
+          #undef _E5_PINS
+          #define _E5_PINS E5_STEP_PIN, E5_DIR_PIN, E5_ENABLE_PIN, _E5_CS _E5_MS1 _E5_MS2 _E5_MS3
+        #endif // EXTRUDERS > 5 || MIXING_EXTRUDER > 5
+      #endif // EXTRUDERS > 4 || MIXING_EXTRUDER > 4
+    #endif // EXTRUDERS > 3 || MIXING_EXTRUDER > 3
+  #endif // EXTRUDERS > 2 || MIXING_EXTRUDER > 2
+#endif // EXTRUDERS > 1 || MIXING_EXTRUDER
+
+//
+// Heaters, Fans, Temp Sensors
+//
+
+#define _H0_PINS HEATER_0_PIN, E0_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_0_PIN),
+#define _H1_PINS
+#define _H2_PINS
+#define _H3_PINS
+#define _H4_PINS
+#define _H5_PINS
+
+#if HOTENDS > 1
+  #undef _H1_PINS
+  #define _H1_PINS HEATER_1_PIN, E1_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_1_PIN),
+  #if HOTENDS > 2
+    #undef _H2_PINS
+    #define _H2_PINS HEATER_2_PIN, E2_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_2_PIN),
+    #if HOTENDS > 3
+      #undef _H3_PINS
+      #define _H3_PINS HEATER_3_PIN, E3_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_3_PIN),
+      #if HOTENDS > 4
+        #undef _H4_PINS
+        #define _H4_PINS HEATER_4_PIN, E4_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_4_PIN),
+        #if HOTENDS > 5
+          #undef _H5_PINS
+          #define _H5_PINS HEATER_5_PIN, E5_AUTO_FAN_PIN, analogInputToDigitalPin(TEMP_5_PIN),
+        #endif // HOTENDS > 5
+      #endif // HOTENDS > 4
+    #endif // HOTENDS > 3
+  #endif // HOTENDS > 2
+#endif // HOTENDS > 1
+
+#define _BED_PINS HEATER_BED_PIN, analogInputToDigitalPin(TEMP_BED_PIN),
+
+//
+// Dual X, Dual Y, Multi-Z
+// Chip Select and Digital Micro-stepping
+//
+
+#if ENABLED(DUAL_X_CARRIAGE) || ENABLED(X_DUAL_STEPPER_DRIVERS)
+  #if PIN_EXISTS(X2_CS)
+    #define _X2_CS X2_CS_PIN,
+  #else
+    #define _X2_CS
+  #endif
+  #if PIN_EXISTS(X2_MS1)
+    #define _X2_MS1 X2_MS1_PIN,
+  #else
+    #define _X2_MS1
+  #endif
+  #if PIN_EXISTS(X2_MS2)
+    #define _X2_MS2 X2_MS2_PIN,
+  #else
+    #define _X2_MS2
+  #endif
+  #if PIN_EXISTS(X2_MS3)
+    #define _X2_MS3 X2_MS3_PIN,
+  #else
+    #define _X2_MS3
+  #endif
+  #define _X2_PINS X2_STEP_PIN, X2_DIR_PIN, X2_ENABLE_PIN, _X2_CS _X2_MS1 _X2_MS2 _X2_MS3
+#else
+  #define _X2_PINS
+#endif
+
+#if ENABLED(Y_DUAL_STEPPER_DRIVERS)
+  #if PIN_EXISTS(Y2_CS)
+    #define _Y2_CS Y2_CS_PIN,
+  #else
+    #define _Y2_CS
+  #endif
+  #if PIN_EXISTS(Y2_MS1)
+    #define _Y2_MS1 Y2_MS1_PIN,
+  #else
+    #define _Y2_MS1
+  #endif
+  #if PIN_EXISTS(Y2_MS2)
+    #define _Y2_MS2 Y2_MS2_PIN,
+  #else
+    #define _Y2_MS2
+  #endif
+  #if PIN_EXISTS(Y2_MS3)
+    #define _Y2_MS3 Y2_MS3_PIN,
+  #else
+    #define _Y2_MS3
+  #endif
+  #define _Y2_PINS Y2_STEP_PIN, Y2_DIR_PIN, Y2_ENABLE_PIN, _Y2_CS _Y2_MS1 _Y2_MS2 _Y2_MS3
+#else
+  #define _Y2_PINS
+#endif
+
+#if Z_MULTI_STEPPER_DRIVERS
+  #if PIN_EXISTS(Z2_CS)
+    #define _Z2_CS Z2_CS_PIN,
+  #else
+    #define _Z2_CS
+  #endif
+  #if PIN_EXISTS(Z2_MS1)
+    #define _Z2_MS1 Z2_MS1_PIN,
+  #else
+    #define _Z2_MS1
+  #endif
+  #if PIN_EXISTS(Z2_MS2)
+    #define _Z2_MS2 Z2_MS2_PIN,
+  #else
+    #define _Z2_MS2
+  #endif
+  #if PIN_EXISTS(Z2_MS3)
+    #define _Z2_MS3 Z2_MS3_PIN,
+  #else
+    #define _Z2_MS3
+  #endif
+  #define _Z2_PINS Z2_STEP_PIN, Z2_DIR_PIN, Z2_ENABLE_PIN, _Z2_CS _Z2_MS1 _Z2_MS2 _Z2_MS3
+#else
+  #define _Z2_PINS
+#endif
+
+#if ENABLED(Z_TRIPLE_STEPPER_DRIVERS)
+  #if PIN_EXISTS(Z3_CS)
+    #define _Z3_CS Z3_CS_PIN,
+  #else
+    #define _Z3_CS
+  #endif
+  #if PIN_EXISTS(Z3_MS1)
+    #define _Z3_MS1 Z3_MS1_PIN,
+  #else
+    #define _Z3_MS1
+  #endif
+  #if PIN_EXISTS(Z3_MS2)
+    #define _Z3_MS2 Z3_MS2_PIN,
+  #else
+    #define _Z3_MS2
+  #endif
+  #if PIN_EXISTS(Z3_MS3)
+    #define _Z3_MS3 Z3_MS3_PIN,
+  #else
+    #define _Z3_MS3
+  #endif
+  #define _Z3_PINS Z3_STEP_PIN, Z3_DIR_PIN, Z3_ENABLE_PIN, _Z3_CS _Z3_MS1 _Z3_MS2 _Z3_MS3
+#else
+  #define _Z3_PINS
+#endif
+
+//
+// Generate the final Sensitive Pins array,
+// keeping the array as small as possible.
+//
+
+#if PIN_EXISTS(PS_ON)
+  #define _PS_ON PS_ON_PIN,
+#else
+  #define _PS_ON
+#endif
+
+#if HAS_BED_PROBE && PIN_EXISTS(Z_MIN_PROBE)
+  #define _Z_PROBE Z_MIN_PROBE_PIN,
+#else
+  #define _Z_PROBE
+#endif
+
+#if TEMP_SENSOR_BED && PIN_EXISTS(HEATER_BED)
+  #define _HEATER_BED HEATER_BED_PIN,
+#else
+  #define _HEATER_BED
+#endif
+
+#if PIN_EXISTS(FAN)
+  #define _FAN0 FAN_PIN,
+#else
+  #define _FAN0
+#endif
+#if PIN_EXISTS(FAN1)
+  #define _FAN1 FAN1_PIN,
+#else
+  #define _FAN1
+#endif
+#if PIN_EXISTS(FAN2)
+  #define _FAN2 FAN2_PIN,
+#else
+  #define _FAN2
+#endif
+#if PIN_EXISTS(CONTROLLER_FAN)
+  #define _FANC CONTROLLER_FAN_PIN,
+#else
+  #define _FANC
+#endif
+
+#ifndef HAL_SENSITIVE_PINS
+  #define HAL_SENSITIVE_PINS
+#endif
+
+#define SENSITIVE_PINS { \
+  _X_PINS _Y_PINS _Z_PINS _X2_PINS _Y2_PINS _Z2_PINS _Z3_PINS _Z_PROBE \
+  _E0_PINS _E1_PINS _E2_PINS _E3_PINS _E4_PINS _E5_PINS _BED_PINS \
+  _H0_PINS _H1_PINS _H2_PINS _H3_PINS _H4_PINS _H5_PINS \
+  _PS_ON _HEATER_BED _FAN0 _FAN1 _FAN2 _FANC \
+  HAL_SENSITIVE_PINS \
+}