diff --git a/Marlin/src/feature/mmu/mmu2.cpp b/Marlin/src/feature/mmu/mmu2.cpp
index 7c3ab0585..a1bec36e4 100644
--- a/Marlin/src/feature/mmu/mmu2.cpp
+++ b/Marlin/src/feature/mmu/mmu2.cpp
@@ -62,29 +62,13 @@ MMU2 mmu2;
 #endif
 
 #define MMU_CMD_NONE 0
-#define MMU_CMD_T0   0x10
-#define MMU_CMD_T1   0x11
-#define MMU_CMD_T2   0x12
-#define MMU_CMD_T3   0x13
-#define MMU_CMD_T4   0x14
-#define MMU_CMD_L0   0x20
-#define MMU_CMD_L1   0x21
-#define MMU_CMD_L2   0x22
-#define MMU_CMD_L3   0x23
-#define MMU_CMD_L4   0x24
+#define MMU_CMD_T0   0x10  // up to supported filaments
+#define MMU_CMD_L0   0x20  // up to supported filaments
 #define MMU_CMD_C0   0x30
 #define MMU_CMD_U0   0x40
-#define MMU_CMD_E0   0x50
-#define MMU_CMD_E1   0x51
-#define MMU_CMD_E2   0x52
-#define MMU_CMD_E3   0x53
-#define MMU_CMD_E4   0x54
+#define MMU_CMD_E0   0x50  // up to supported filaments
 #define MMU_CMD_R0   0x60
-#define MMU_CMD_F0   0x70
-#define MMU_CMD_F1   0x71
-#define MMU_CMD_F2   0x72
-#define MMU_CMD_F3   0x73
-#define MMU_CMD_F4   0x74
+#define MMU_CMD_F0   0x70  // up to supported filaments
 
 #define MMU_REQUIRED_FW_BUILDNR TERN(MMU2_MODE_12V, 132, 126)
 
@@ -243,7 +227,7 @@ void MMU2::mmu_loop() {
 
     case 1:
       if (cmd) {
-        if (WITHIN(cmd, MMU_CMD_T0, MMU_CMD_T4)) {
+        if (WITHIN(cmd, MMU_CMD_T0, MMU_CMD_T0 + EXTRUDERS - 1)) {
           // tool change
           int filament = cmd - MMU_CMD_T0;
           DEBUG_ECHOLNPAIR("MMU <= T", filament);
@@ -251,7 +235,7 @@ void MMU2::mmu_loop() {
           TERN_(MMU_EXTRUDER_SENSOR, mmu_idl_sens = 1); // enable idler sensor, if any
           state = 3; // wait for response
         }
-        else if (WITHIN(cmd, MMU_CMD_L0, MMU_CMD_L4)) {
+        else if (WITHIN(cmd, MMU_CMD_L0, MMU_CMD_L0 + EXTRUDERS - 1)) {
           // load
           int filament = cmd - MMU_CMD_L0;
           DEBUG_ECHOLNPAIR("MMU <= L", filament);
@@ -271,7 +255,7 @@ void MMU2::mmu_loop() {
           MMU2_COMMAND("U0");
           state = 3; // wait for response
         }
-        else if (WITHIN(cmd, MMU_CMD_E0, MMU_CMD_E4)) {
+        else if (WITHIN(cmd, MMU_CMD_E0, MMU_CMD_E0 + EXTRUDERS - 1)) {
           // eject filament
           int filament = cmd - MMU_CMD_E0;
           DEBUG_ECHOLNPAIR("MMU <= E", filament);
@@ -284,7 +268,7 @@ void MMU2::mmu_loop() {
           MMU2_COMMAND("R0");
           state = 3; // wait for response
         }
-        else if (WITHIN(cmd, MMU_CMD_F0, MMU_CMD_F4)) {
+        else if (WITHIN(cmd, MMU_CMD_F0, MMU_CMD_F0 + EXTRUDERS - 1)) {
           // filament type
           int filament = cmd - MMU_CMD_F0;
           DEBUG_ECHOLNPAIR("MMU <= F", filament, " ", cmd_arg);
diff --git a/Marlin/src/gcode/feature/prusa_MMU2/M403.cpp b/Marlin/src/gcode/feature/prusa_MMU2/M403.cpp
index 31d076337..bca2013e8 100644
--- a/Marlin/src/gcode/feature/prusa_MMU2/M403.cpp
+++ b/Marlin/src/gcode/feature/prusa_MMU2/M403.cpp
@@ -40,7 +40,7 @@ void GcodeSuite::M403() {
   int8_t index = parser.intval('E', -1),
          type = parser.intval('F', -1);
 
-  if (WITHIN(index, 0, 4) && WITHIN(type, 0, 2))
+  if (WITHIN(index, 0, EXTRUDERS - 1) && WITHIN(type, 0, 2))
     mmu2.set_filament_type(index, type);
   else
     SERIAL_ECHO_MSG("M403 - bad arguments.");
diff --git a/Marlin/src/inc/Conditionals_LCD.h b/Marlin/src/inc/Conditionals_LCD.h
index cff1424eb..3e20bb90c 100644
--- a/Marlin/src/inc/Conditionals_LCD.h
+++ b/Marlin/src/inc/Conditionals_LCD.h
@@ -513,7 +513,7 @@
     #define HAS_PRUSA_MMU2 1
     #define HAS_PRUSA_MMU2S 1
   #endif
-  #if MMU_MODEL >= SMUFF_EMU_MMU2
+  #if MMU_MODEL == SMUFF_EMU_MMU2 || MMU_MODEL == SMUFF_EMU_MMU2S
     #define HAS_SMUFF 1
   #endif
 #endif