diff --git a/Marlin/stepper_indirection.h b/Marlin/stepper_indirection.h
index b14dde795..4052e395f 100644
--- a/Marlin/stepper_indirection.h
+++ b/Marlin/stepper_indirection.h
@@ -195,14 +195,14 @@
   #define NORM_E_DIR() { switch (current_block->active_extruder) { case 0: E0_DIR_WRITE(!INVERT_E0_DIR); break; case 1: E1_DIR_WRITE(!INVERT_E1_DIR); break; case 2: E2_DIR_WRITE(!INVERT_E2_DIR); } }
   #define REV_E_DIR() { switch (current_block->active_extruder) { case 0: E0_DIR_WRITE(INVERT_E0_DIR); break; case 1: E1_DIR_WRITE(INVERT_E1_DIR); break; case 2: E2_DIR_WRITE(INVERT_E2_DIR); } }
 #elif EXTRUDERS > 1
-  #if DISABLED(DUAL_X_CARRIAGE) && DISABLED(DUAL_NOZZLE_DUPLICATION_MODE)
-    #define E_STEP_WRITE(v) { if (current_block->active_extruder == 0) { E0_STEP_WRITE(v); } else { E1_STEP_WRITE(v); } }
-    #define NORM_E_DIR() { if (current_block->active_extruder == 0) { E0_DIR_WRITE(!INVERT_E0_DIR); } else { E1_DIR_WRITE(!INVERT_E1_DIR); } }
-    #define REV_E_DIR() { if (current_block->active_extruder == 0) { E0_DIR_WRITE(INVERT_E0_DIR); } else { E1_DIR_WRITE(INVERT_E1_DIR); } }
-  #else
+  #if ENABLED(DUAL_X_CARRIAGE) || ENABLED(DUAL_NOZZLE_DUPLICATION_MODE)
     #define E_STEP_WRITE(v) { if (extruder_duplication_enabled) { E0_STEP_WRITE(v); E1_STEP_WRITE(v); } else if (current_block->active_extruder == 0) { E0_STEP_WRITE(v); } else { E1_STEP_WRITE(v); } }
     #define NORM_E_DIR() { if (extruder_duplication_enabled) { E0_DIR_WRITE(!INVERT_E0_DIR); E1_DIR_WRITE(!INVERT_E1_DIR); } else if (current_block->active_extruder == 0) { E0_DIR_WRITE(!INVERT_E0_DIR); } else { E1_DIR_WRITE(!INVERT_E1_DIR); } }
     #define REV_E_DIR() { if (extruder_duplication_enabled) { E0_DIR_WRITE(INVERT_E0_DIR); E1_DIR_WRITE(INVERT_E1_DIR); } else if (current_block->active_extruder == 0) { E0_DIR_WRITE(INVERT_E0_DIR); } else { E1_DIR_WRITE(INVERT_E1_DIR); } }
+  #else
+    #define E_STEP_WRITE(v) { if (current_block->active_extruder == 0) { E0_STEP_WRITE(v); } else { E1_STEP_WRITE(v); } }
+    #define NORM_E_DIR() { if (current_block->active_extruder == 0) { E0_DIR_WRITE(!INVERT_E0_DIR); } else { E1_DIR_WRITE(!INVERT_E1_DIR); } }
+    #define REV_E_DIR() { if (current_block->active_extruder == 0) { E0_DIR_WRITE(INVERT_E0_DIR); } else { E1_DIR_WRITE(INVERT_E1_DIR); } }
   #endif
 #elif ENABLED(MIXING_EXTRUDER)
   #define E_STEP_WRITE(v) NOOP /* not used for mixing extruders! */