diff --git a/Marlin/src/HAL/LPC1768/MarlinSerial.cpp b/Marlin/src/HAL/LPC1768/MarlinSerial.cpp
index 454ace33b..c636a40a1 100644
--- a/Marlin/src/HAL/LPC1768/MarlinSerial.cpp
+++ b/Marlin/src/HAL/LPC1768/MarlinSerial.cpp
@@ -24,19 +24,19 @@
 #include "../../inc/MarlinConfigPre.h"
 #include "MarlinSerial.h"
 
-#if USING_SERIAL_0
+#if ANY_SERIAL_IS(0)
   MSerialT MSerial(true, LPC_UART0);
   extern "C" void UART0_IRQHandler() { MSerial.IRQHandler(); }
 #endif
-#if USING_SERIAL_1
+#if ANY_SERIAL_IS(1)
   MSerialT MSerial1(true, (LPC_UART_TypeDef *) LPC_UART1);
   extern "C" void UART1_IRQHandler() { MSerial1.IRQHandler(); }
 #endif
-#if USING_SERIAL_2
+#if ANY_SERIAL_IS(2)
   MSerialT MSerial2(true, LPC_UART2);
   extern "C" void UART2_IRQHandler() { MSerial2.IRQHandler(); }
 #endif
-#if USING_SERIAL_3
+#if ANY_SERIAL_IS(3)
   MSerialT MSerial3(true, LPC_UART3);
   extern "C" void UART3_IRQHandler() { MSerial3.IRQHandler(); }
 #endif
diff --git a/Marlin/src/HAL/LPC1768/inc/SanityCheck.h b/Marlin/src/HAL/LPC1768/inc/SanityCheck.h
index 14890bcd6..be64ea832 100644
--- a/Marlin/src/HAL/LPC1768/inc/SanityCheck.h
+++ b/Marlin/src/HAL/LPC1768/inc/SanityCheck.h
@@ -92,7 +92,7 @@ static_assert(DISABLED(BAUD_RATE_GCODE), "BAUD_RATE_GCODE is not yet supported o
 #define ANY_TX(N,V...) DO(IS_TX##N,||,V)
 #define ANY_RX(N,V...) DO(IS_RX##N,||,V)
 
-#if USING_SERIAL_0
+#if ANY_SERIAL_IS(0)
   #define IS_TX0(P) (P == P0_02)
   #define IS_RX0(P) (P == P0_03)
   #if IS_TX0(TMC_SW_MISO) || IS_RX0(TMC_SW_MOSI)
@@ -106,7 +106,7 @@ static_assert(DISABLED(BAUD_RATE_GCODE), "BAUD_RATE_GCODE is not yet supported o
   #undef IS_RX0
 #endif
 
-#if USING_SERIAL_1
+#if ANY_SERIAL_IS(1)
   #define IS_TX1(P) (P == P0_15)
   #define IS_RX1(P) (P == P0_16)
   #define _IS_TX1_1 IS_TX1
@@ -127,7 +127,7 @@ static_assert(DISABLED(BAUD_RATE_GCODE), "BAUD_RATE_GCODE is not yet supported o
   #undef _IS_RX1_1
 #endif
 
-#if USING_SERIAL_2
+#if ANY_SERIAL_IS(2)
   #define IS_TX2(P) (P == P0_10)
   #define IS_RX2(P) (P == P0_11)
   #define _IS_TX2_1 IS_TX2
@@ -161,7 +161,7 @@ static_assert(DISABLED(BAUD_RATE_GCODE), "BAUD_RATE_GCODE is not yet supported o
   #undef _IS_RX2_1
 #endif
 
-#if USING_SERIAL_3
+#if ANY_SERIAL_IS(3)
   #define PIN_IS_TX3(P) (PIN_EXISTS(P) && P##_PIN == P0_00)
   #define PIN_IS_RX3(P) (P##_PIN == P0_01)
   #if PIN_IS_TX3(X_MIN) || PIN_IS_RX3(X_MAX)
diff --git a/Marlin/src/HAL/SAMD51/MarlinSerial_AGCM4.cpp b/Marlin/src/HAL/SAMD51/MarlinSerial_AGCM4.cpp
index ce32eafee..3f43585cf 100644
--- a/Marlin/src/HAL/SAMD51/MarlinSerial_AGCM4.cpp
+++ b/Marlin/src/HAL/SAMD51/MarlinSerial_AGCM4.cpp
@@ -27,7 +27,7 @@
 
 #include "../../inc/MarlinConfig.h"
 
-#if USING_SERIAL_1
+#if ANY_SERIAL_IS(1)
   UartT Serial2(false, &sercom4, PIN_SERIAL2_RX, PIN_SERIAL2_TX, PAD_SERIAL2_RX, PAD_SERIAL2_TX);
   void SERCOM4_0_Handler() { Serial2.IrqHandler(); }
   void SERCOM4_1_Handler() { Serial2.IrqHandler(); }
@@ -35,7 +35,7 @@
   void SERCOM4_3_Handler() { Serial2.IrqHandler(); }
 #endif
 
-#if USING_SERIAL_2
+#if ANY_SERIAL_IS(2)
   UartT Serial3(false, &sercom1, PIN_SERIAL3_RX, PIN_SERIAL3_TX, PAD_SERIAL3_RX, PAD_SERIAL3_TX);
   void SERCOM1_0_Handler() { Serial3.IrqHandler(); }
   void SERCOM1_1_Handler() { Serial3.IrqHandler(); }
@@ -43,7 +43,7 @@
   void SERCOM1_3_Handler() { Serial3.IrqHandler(); }
 #endif
 
-#if USING_SERIAL_3
+#if ANY_SERIAL_IS(3)
   UartT Serial4(false, &sercom5, PIN_SERIAL4_RX, PIN_SERIAL4_TX, PAD_SERIAL4_RX, PAD_SERIAL4_TX);
   void SERCOM5_0_Handler() { Serial4.IrqHandler(); }
   void SERCOM5_1_Handler() { Serial4.IrqHandler(); }
diff --git a/Marlin/src/inc/Conditionals_adv.h b/Marlin/src/inc/Conditionals_adv.h
index 22a671c5b..d6245718f 100644
--- a/Marlin/src/inc/Conditionals_adv.h
+++ b/Marlin/src/inc/Conditionals_adv.h
@@ -516,34 +516,3 @@
                          (defined(SERIAL_PORT_2) && SERIAL_PORT_2 == (N)) || \
                          (defined(MMU2_SERIAL_PORT) && MMU2_SERIAL_PORT == (N)) || \
                          (defined(LCD_SERIAL_PORT) && LCD_SERIAL_PORT == (N))
-#if ANY_SERIAL_IS(-1)
-  #define USING_SERIAL_DEFAULT
-#endif
-#if ANY_SERIAL_IS(0)
-  #define USING_SERIAL_0 1
-#endif
-#if ANY_SERIAL_IS(1)
-  #define USING_SERIAL_1 1
-#endif
-#if ANY_SERIAL_IS(2)
-  #define USING_SERIAL_2 1
-#endif
-#if ANY_SERIAL_IS(3)
-  #define USING_SERIAL_3 1
-#endif
-#if ANY_SERIAL_IS(4)
-  #define USING_SERIAL_4 1
-#endif
-#if ANY_SERIAL_IS(5)
-  #define USING_SERIAL_5 1
-#endif
-#if ANY_SERIAL_IS(6)
-  #define USING_SERIAL_6 1
-#endif
-#if ANY_SERIAL_IS(7)
-  #define USING_SERIAL_7 1
-#endif
-#if ANY_SERIAL_IS(8)
-  #define USING_SERIAL_8 1
-#endif
-#undef ANY_SERIAL_IS