diff --git a/Marlin/src/lcd/marlinui.cpp b/Marlin/src/lcd/marlinui.cpp
index 1d312535c..544cc5eb2 100644
--- a/Marlin/src/lcd/marlinui.cpp
+++ b/Marlin/src/lcd/marlinui.cpp
@@ -681,7 +681,7 @@ void MarlinUI::quick_feedback(const bool clear_buttons/*=true*/) {
     xyze_pos_t ManualMove::all_axes_destination = { 0 };
     bool ManualMove::processing = false;
   #endif
-  #if ENABLED(MULTI_MANUAL)
+  #if ENABLED(MULTI_E_MANUAL)
     int8_t ManualMove::e_index = 0;
   #endif
   AxisEnum ManualMove::axis = NO_AXIS_MASK;
@@ -758,11 +758,11 @@ void MarlinUI::quick_feedback(const bool clear_buttons/*=true*/) {
   // Tell ui.update() to start a move to current_position after a short delay.
   //
   void ManualMove::soon(const AxisEnum move_axis
-    #if MULTI_MANUAL
+    #if MULTI_E_MANUAL
       , const int8_t eindex/*=-1*/
     #endif
   ) {
-    #if MULTI_MANUAL
+    #if MULTI_E_MANUAL
       if (move_axis == E_AXIS) e_index = eindex >= 0 ? eindex : active_extruder;
     #endif
     start_time = millis() + (menu_scale < 0.99f ? 0UL : 250UL); // delay for bigger moves
diff --git a/Marlin/src/lcd/marlinui.h b/Marlin/src/lcd/marlinui.h
index 085e2e0b7..ba0221713 100644
--- a/Marlin/src/lcd/marlinui.h
+++ b/Marlin/src/lcd/marlinui.h
@@ -48,7 +48,7 @@
 #endif
 
 #if E_MANUAL > 1
-  #define MULTI_MANUAL 1
+  #define MULTI_E_MANUAL 1
 #endif
 
 #if HAS_DISPLAY
@@ -129,7 +129,7 @@
   class ManualMove {
   private:
     static AxisEnum axis;
-    #if MULTI_MANUAL
+    #if MULTI_E_MANUAL
       static int8_t e_index;
     #else
       static int8_t constexpr e_index = 0;
@@ -183,7 +183,7 @@
     #endif
     static void task();
     static void soon(const AxisEnum axis
-      #if MULTI_MANUAL
+      #if MULTI_E_MANUAL
         , const int8_t eindex=-1
       #endif
     );
diff --git a/Marlin/src/lcd/menu/menu_motion.cpp b/Marlin/src/lcd/menu/menu_motion.cpp
index 6bf6df189..06d635ffc 100644
--- a/Marlin/src/lcd/menu/menu_motion.cpp
+++ b/Marlin/src/lcd/menu/menu_motion.cpp
@@ -94,14 +94,14 @@ void lcd_move_z() { _lcd_move_xyz(GET_TEXT(MSG_MOVE_Z), Z_AXIS); }
 
 #if E_MANUAL
 
-  static void lcd_move_e(TERN_(MULTI_MANUAL, const int8_t eindex=-1)) {
+  static void lcd_move_e(TERN_(MULTI_E_MANUAL, const int8_t eindex=-1)) {
     if (ui.use_click()) return ui.goto_previous_screen_no_defer();
     if (ui.encoderPosition) {
       if (!ui.manual_move.processing) {
         const float diff = float(int32_t(ui.encoderPosition)) * ui.manual_move.menu_scale;
         TERN(IS_KINEMATIC, ui.manual_move.offset, current_position.e) += diff;
         ui.manual_move.soon(E_AXIS
-          #if MULTI_MANUAL
+          #if MULTI_E_MANUAL
             , eindex
           #endif
         );
@@ -110,9 +110,9 @@ void lcd_move_z() { _lcd_move_xyz(GET_TEXT(MSG_MOVE_Z), Z_AXIS); }
       ui.encoderPosition = 0;
     }
     if (ui.should_draw()) {
-      TERN_(MULTI_MANUAL, MenuItemBase::init(eindex));
+      TERN_(MULTI_E_MANUAL, MenuItemBase::init(eindex));
       MenuEditItemBase::draw_edit_screen(
-        GET_TEXT(TERN(MULTI_MANUAL, MSG_MOVE_EN, MSG_MOVE_E)),
+        GET_TEXT(TERN(MULTI_E_MANUAL, MSG_MOVE_EN, MSG_MOVE_E)),
         ftostr41sign(current_position.e
           PLUS_TERN0(IS_KINEMATIC, ui.manual_move.offset)
           MINUS_TERN0(MANUAL_E_MOVES_RELATIVE, manual_move_e_origin)
@@ -188,7 +188,7 @@ void _menu_move_distance(const AxisEnum axis, const screenFunc_t func, const int
 #if E_MANUAL
 
   inline void _goto_menu_move_distance_e() {
-    ui.goto_screen([]{ _menu_move_distance(E_AXIS, []{ lcd_move_e(TERN_(MULTI_MANUAL, active_extruder)); }, -1); });
+    ui.goto_screen([]{ _menu_move_distance(E_AXIS, []{ lcd_move_e(TERN_(MULTI_E_MANUAL, active_extruder)); }, -1); });
   }
 
   inline void _menu_move_distance_e_maybe() {
@@ -283,7 +283,7 @@ void menu_move() {
         SUBMENU_MOVE_E(E_MANUAL - 1);
       #endif
 
-    #elif MULTI_MANUAL
+    #elif MULTI_E_MANUAL
 
       // Independent extruders with one E-stepper per hotend
       LOOP_L_N(n, E_MANUAL) SUBMENU_MOVE_E(n);
diff --git a/Marlin/src/lcd/tft/ui_1024x600.cpp b/Marlin/src/lcd/tft/ui_1024x600.cpp
index 3b12ab2b6..87b016b1e 100644
--- a/Marlin/src/lcd/tft/ui_1024x600.cpp
+++ b/Marlin/src/lcd/tft/ui_1024x600.cpp
@@ -725,7 +725,7 @@ static void moveAxis(const AxisEnum axis, const int8_t direction) {
     #endif
 
     ui.manual_move.soon(axis
-      #if MULTI_MANUAL
+      #if MULTI_E_MANUAL
         , motionAxisState.e_selection
       #endif
     );
diff --git a/Marlin/src/lcd/tft/ui_320x240.cpp b/Marlin/src/lcd/tft/ui_320x240.cpp
index 31665fdc3..89a127b01 100644
--- a/Marlin/src/lcd/tft/ui_320x240.cpp
+++ b/Marlin/src/lcd/tft/ui_320x240.cpp
@@ -710,7 +710,7 @@ static void moveAxis(const AxisEnum axis, const int8_t direction) {
     #endif
 
     ui.manual_move.soon(axis
-      #if MULTI_MANUAL
+      #if MULTI_E_MANUAL
         , motionAxisState.e_selection
       #endif
     );
diff --git a/Marlin/src/lcd/tft/ui_480x320.cpp b/Marlin/src/lcd/tft/ui_480x320.cpp
index a5539990d..6923bdd71 100644
--- a/Marlin/src/lcd/tft/ui_480x320.cpp
+++ b/Marlin/src/lcd/tft/ui_480x320.cpp
@@ -712,7 +712,7 @@ static void moveAxis(const AxisEnum axis, const int8_t direction) {
     #endif
 
     ui.manual_move.soon(axis
-      #if MULTI_MANUAL
+      #if MULTI_E_MANUAL
         , motionAxisState.e_selection
       #endif
     );