diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index 9032f4d2d..8bbc50bee 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -3369,6 +3369,37 @@
   #define GCODE_MACROS_SLOT_SIZE  50  // Maximum length of a single macro
 #endif
 
+/**
+ * User-defined buttons to run custom G-code.
+ * Up to 25 may be defined.
+ */
+//#define CUSTOM_USER_BUTTONS
+#if ENABLED(CUSTOM_USER_BUTTONS)
+  //#define BUTTON1_PIN -1
+  #if PIN_EXISTS(BUTTON1_PIN)
+    #define BUTTON1_HIT_STATE     LOW       // State of the triggered button. NC=LOW. NO=HIGH.
+    #define BUTTON1_WHEN_PRINTING false     // Button allowed to trigger during printing?
+    #define BUTTON1_GCODE         "G28"
+    #define BUTTON1_DESC          "Homing"  // Optional string to set the LCD status
+  #endif
+
+  //#define BUTTON2_PIN -1
+  #if PIN_EXISTS(BUTTON2_PIN)
+    #define BUTTON2_HIT_STATE     LOW
+    #define BUTTON2_WHEN_PRINTING false
+    #define BUTTON2_GCODE         "M140 S" STRINGIFY(PREHEAT_1_TEMP_BED) "\nM104 S" STRINGIFY(PREHEAT_1_TEMP_HOTEND)
+    #define BUTTON2_DESC          "Preheat for " PREHEAT_1_LABEL
+  #endif
+
+  //#define BUTTON3_PIN -1
+  #if PIN_EXISTS(BUTTON3_PIN)
+    #define BUTTON3_HIT_STATE     LOW
+    #define BUTTON3_WHEN_PRINTING false
+    #define BUTTON3_GCODE         "M140 S" STRINGIFY(PREHEAT_2_TEMP_BED) "\nM104 S" STRINGIFY(PREHEAT_2_TEMP_HOTEND)
+    #define BUTTON3_DESC          "Preheat for " PREHEAT_2_LABEL
+  #endif
+#endif
+
 /**
  * User-defined menu items to run custom G-code.
  * Up to 25 may be defined, but the actual number is LCD-dependent.
diff --git a/Marlin/src/MarlinCore.cpp b/Marlin/src/MarlinCore.cpp
index 751d09860..689650c6a 100644
--- a/Marlin/src/MarlinCore.cpp
+++ b/Marlin/src/MarlinCore.cpp
@@ -406,6 +406,7 @@ void startOrResumeJob() {
  *  - Check if CHDK_PIN needs to go LOW
  *  - Check for KILL button held down
  *  - Check for HOME button held down
+ *  - Check for CUSTOM USER button held down
  *  - Check if cooling fan needs to be switched on
  *  - Check if an idle but hot extruder needs filament extruded (EXTRUDER_RUNOUT_PREVENT)
  *  - Pulse FET_SAFETY_PIN if it exists
@@ -498,6 +499,102 @@ inline void manage_inactivity(const bool ignore_stepper_queue=false) {
     }
   #endif
 
+  #if ENABLED(CUSTOM_USER_BUTTONS)
+    // Handle a custom user button if defined
+    const bool printer_not_busy = !printingIsActive();
+    #define HAS_CUSTOM_USER_BUTTON(N) (PIN_EXISTS(BUTTON##N) && defined(BUTTON##N##_HIT_STATE) && defined(BUTTON##N##_GCODE) && defined(BUTTON##N##_DESC))
+    #define CHECK_CUSTOM_USER_BUTTON(N) do{                            \
+      constexpr millis_t CUB_DEBOUNCE_DELAY_##N = 250UL;               \
+      static millis_t next_cub_ms_##N;                                 \
+      if (BUTTON##N##_HIT_STATE == READ(BUTTON##N##_PIN)               \
+        && (ENABLED(BUTTON##N##_WHEN_PRINTING) || printer_not_busy)) { \
+        const millis_t ms = millis();                                  \
+        if (ELAPSED(ms, next_cub_ms_##N)) {                            \
+          next_cub_ms_##N = ms + CUB_DEBOUNCE_DELAY_##N;               \
+          if (strlen(BUTTON##N##_DESC))                                \
+            LCD_MESSAGEPGM_P(PSTR(BUTTON##N##_DESC));                  \
+          queue.inject_P(PSTR(BUTTON##N##_GCODE));                     \
+        }                                                              \
+      }                                                                \
+    }while(0)
+
+    #if HAS_CUSTOM_USER_BUTTON(1)
+      CHECK_CUSTOM_USER_BUTTON(1);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(2)
+      CHECK_CUSTOM_USER_BUTTON(2);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(3)
+      CHECK_CUSTOM_USER_BUTTON(3);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(4)
+      CHECK_CUSTOM_USER_BUTTON(4);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(5)
+      CHECK_CUSTOM_USER_BUTTON(5);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(6)
+      CHECK_CUSTOM_USER_BUTTON(6);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(7)
+      CHECK_CUSTOM_USER_BUTTON(7);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(8)
+      CHECK_CUSTOM_USER_BUTTON(8);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(9)
+      CHECK_CUSTOM_USER_BUTTON(9);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(10)
+      CHECK_CUSTOM_USER_BUTTON(10);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(11)
+      CHECK_CUSTOM_USER_BUTTON(11);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(12)
+      CHECK_CUSTOM_USER_BUTTON(12);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(13)
+      CHECK_CUSTOM_USER_BUTTON(13);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(14)
+      CHECK_CUSTOM_USER_BUTTON(14);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(15)
+      CHECK_CUSTOM_USER_BUTTON(15);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(16)
+      CHECK_CUSTOM_USER_BUTTON(16);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(17)
+      CHECK_CUSTOM_USER_BUTTON(17);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(18)
+      CHECK_CUSTOM_USER_BUTTON(18);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(19)
+      CHECK_CUSTOM_USER_BUTTON(19);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(20)
+      CHECK_CUSTOM_USER_BUTTON(20);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(21)
+      CHECK_CUSTOM_USER_BUTTON(21);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(22)
+      CHECK_CUSTOM_USER_BUTTON(22);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(23)
+      CHECK_CUSTOM_USER_BUTTON(23);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(24)
+      CHECK_CUSTOM_USER_BUTTON(24);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(25)
+      CHECK_CUSTOM_USER_BUTTON(25);
+    #endif
+  #endif
+
   TERN_(USE_CONTROLLER_FAN, controllerFan.update()); // Check if fan should be turned on to cool stepper drivers down
 
   TERN_(AUTO_POWER_CONTROL, powerManager.check());
@@ -857,7 +954,7 @@ inline void tmc_standby_setup() {
 
 /**
  * Marlin entry-point: Set up before the program loop
- *  - Set up the kill pin, filament runout, power hold
+ *  - Set up the kill pin, filament runout, power hold, custom user buttons
  *  - Start the serial port
  *  - Print startup messages and diagnostics
  *  - Get EEPROM or default settings
@@ -1131,6 +1228,86 @@ void setup() {
     SET_INPUT_PULLUP(HOME_PIN);
   #endif
 
+  #if ENABLED(CUSTOM_USER_BUTTONS)
+    #define INIT_CUSTOM_USER_BUTTON_PIN(N) do{ SET_INPUT(BUTTON##N##_PIN); WRITE(BUTTON##N##_PIN, !BUTTON##N##_HIT_STATE); }while(0)
+
+    #if HAS_CUSTOM_USER_BUTTON(1)
+      INIT_CUSTOM_USER_BUTTON_PIN(1);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(2)
+      INIT_CUSTOM_USER_BUTTON_PIN(2);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(3)
+      INIT_CUSTOM_USER_BUTTON_PIN(3);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(4)
+      INIT_CUSTOM_USER_BUTTON_PIN(4);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(5)
+      INIT_CUSTOM_USER_BUTTON_PIN(5);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(6)
+      INIT_CUSTOM_USER_BUTTON_PIN(6);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(7)
+      INIT_CUSTOM_USER_BUTTON_PIN(7);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(8)
+      INIT_CUSTOM_USER_BUTTON_PIN(8);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(9)
+      INIT_CUSTOM_USER_BUTTON_PIN(9);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(10)
+      INIT_CUSTOM_USER_BUTTON_PIN(10);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(11)
+      INIT_CUSTOM_USER_BUTTON_PIN(11);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(12)
+      INIT_CUSTOM_USER_BUTTON_PIN(12);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(13)
+      INIT_CUSTOM_USER_BUTTON_PIN(13);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(14)
+      INIT_CUSTOM_USER_BUTTON_PIN(14);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(15)
+      INIT_CUSTOM_USER_BUTTON_PIN(15);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(16)
+      INIT_CUSTOM_USER_BUTTON_PIN(16);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(17)
+      INIT_CUSTOM_USER_BUTTON_PIN(17);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(18)
+      INIT_CUSTOM_USER_BUTTON_PIN(18);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(19)
+      INIT_CUSTOM_USER_BUTTON_PIN(19);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(20)
+      INIT_CUSTOM_USER_BUTTON_PIN(20);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(21)
+      INIT_CUSTOM_USER_BUTTON_PIN(21);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(22)
+      INIT_CUSTOM_USER_BUTTON_PIN(22);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(23)
+      INIT_CUSTOM_USER_BUTTON_PIN(23);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(24)
+      INIT_CUSTOM_USER_BUTTON_PIN(24);
+    #endif
+    #if HAS_CUSTOM_USER_BUTTON(25)
+      INIT_CUSTOM_USER_BUTTON_PIN(25);
+    #endif
+  #endif
+
   #if PIN_EXISTS(STAT_LED_RED)
     OUT_WRITE(STAT_LED_RED_PIN, LOW); // OFF
   #endif
diff --git a/Marlin/src/pins/pinsDebug_list.h b/Marlin/src/pins/pinsDebug_list.h
index 79a67c34f..42095fa92 100644
--- a/Marlin/src/pins/pinsDebug_list.h
+++ b/Marlin/src/pins/pinsDebug_list.h
@@ -183,6 +183,81 @@
 #if PIN_EXISTS(JOY_EN)
   REPORT_NAME_DIGITAL(__LINE__, JOY_EN_PIN)
 #endif
+#if PIN_EXISTS(BUTTON1)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON1_PIN)
+#endif
+#if PIN_EXISTS(BUTTON2)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON2_PIN)
+#endif
+#if PIN_EXISTS(BUTTON3)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON3_PIN)
+#endif
+#if PIN_EXISTS(BUTTON4)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON4_PIN)
+#endif
+#if PIN_EXISTS(BUTTON5)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON5_PIN)
+#endif
+#if PIN_EXISTS(BUTTON6)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON6_PIN)
+#endif
+#if PIN_EXISTS(BUTTON7)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON7_PIN)
+#endif
+#if PIN_EXISTS(BUTTON8)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON8_PIN)
+#endif
+#if PIN_EXISTS(BUTTON9)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON9_PIN)
+#endif
+#if PIN_EXISTS(BUTTON10)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON10_PIN)
+#endif
+#if PIN_EXISTS(BUTTON11)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON11_PIN)
+#endif
+#if PIN_EXISTS(BUTTON12)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON12_PIN)
+#endif
+#if PIN_EXISTS(BUTTON13)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON13_PIN)
+#endif
+#if PIN_EXISTS(BUTTON14)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON14_PIN)
+#endif
+#if PIN_EXISTS(BUTTON15)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON15_PIN)
+#endif
+#if PIN_EXISTS(BUTTON16)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON16_PIN)
+#endif
+#if PIN_EXISTS(BUTTON17)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON17_PIN)
+#endif
+#if PIN_EXISTS(BUTTON18)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON18_PIN)
+#endif
+#if PIN_EXISTS(BUTTON19)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON19_PIN)
+#endif
+#if PIN_EXISTS(BUTTON20)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON20_PIN)
+#endif
+#if PIN_EXISTS(BUTTON21)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON21_PIN)
+#endif
+#if PIN_EXISTS(BUTTON22)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON22_PIN)
+#endif
+#if PIN_EXISTS(BUTTON23)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON23_PIN)
+#endif
+#if PIN_EXISTS(BUTTON24)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON24_PIN)
+#endif
+#if PIN_EXISTS(BUTTON25)
+  REPORT_NAME_DIGITAL(__LINE__, BUTTON25_PIN)
+#endif
 #if PIN_EXISTS(CASE_LIGHT)
   REPORT_NAME_DIGITAL(__LINE__, CASE_LIGHT_PIN)
 #endif